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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 474-320-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Administrative data
First-aid measures
Emergency measure - Inhalation: Remove to fresh air. If any trouble breathing, get immediate
medical attention. Administer artificial respiration if
breathing has ceased. If irritation or symptoms occur or
persist, consult a physician.
Emergency measure - Eyes: In case of eye contact, immediately rinse eyes thoroughly
with plenty of water. If wearing contact lenses, remove only
after initial rinse, and continue rinsing eyes for at
least 15 minutes. If irritation occurs or persists, consult
a physician.
Emergency measure - Skin: In case of skin contact, while wearing protective gloves,
carefully remove any contaminated clothing, including shoes,
and wash skin thoroughly with soap and water. If irritation
or symptoms occur or persist, consult a physician.
Emergency measure - Ingestion: Rinse mouth and drink a glass of water. Do not induce
vomiting unless under the direction of a qualified medical
professional or Poison Control Center. If symptoms persist,
consult a physician.
Fire-fighting measures
Recommended extinguishing agent: Carbon dioxide (CO2), extinguishing powder or water spray.
Product arising from burning: Combustion products may contain CO, CO2, and water.
Product determined by test: N
Protective equipment: Wear full protective clothing and self-contained breathing
apparatus.
Accidental release measures
Emergency measures in case of spillage: All spills should be handled according to site requirements.
In the case of liquids, use proper absorbent materials.
Forlaboratories and small-scale operations, incidental
spills within a hood or enclosure should be cleaned by using
a HEPA filtered vacuum or wet cleaning methods as
appropriate. For large dry or liquid spills or those spills
outside enclosure or hood, appropriate emergency response
personnel should be notified. In manufacturing and large-
scale operations, HEPA vacuuming prior to wet mopping or
cleaning is required.
Handling and storage
Handling: Observe usual precautions for handling chemicals. Ensure
adequate ventilation while handling the substance. Avoid
inhalation, contact with skin and eyes. Wear suitable
protective gloves and safety goggles. Wash thoroughly after
handling.
Schering-Plough Global Industrial Hygiene Services (GIHS)
has established standards for the Schering-Plough Industrial
Hygiene Risk Management (IHRM) Program to provide guidance
for protection of persons who handle Schering-Plough
materials, as well as materials purchased, for the research
and manufacture of Schering-Plough substances and
preparations. This program is used at all Schering-Plough
facilities worldwide. Key features of the IHRM include, but
are not limited to, Industrial Hygiene Risk Assessment
(IHRA) and Risk-Based Exposure Control Strategies (R-BECS).
IHRA is designed to evaluate each task or operation by
assessment of the hazard and potential degrees of exposure
to establish the actual risk of exposure by a worker
performing specific tasks. The health hazard of a material
is determined by Schering-Plough Global Occupational &
Environmental Toxicology and is used as the 'hazard'
component of the two-dimensional model. The hazard is
assessed against potential degrees of exposure that include
such elements as physical form of the substance, volume or
quantity used, duration and frequency of handling, etc.
From this assessment, the use of the substance is classified
as a low to high exposure risk which is then used to
determine exposure control strategies, need for industrial
hygiene monitoring, and appropriate personal protective
equipment usage. All personal protective equipment (PPE) is
chosen in accordance to local requirements and regulations
and is documented in the IHRA for that process.
The principles of the IHRA are communicated on Schering-
Plough Safety Data Sheets (SDSs) in appropriate sections
(e.g. section 8). Because of the global use of the SDSs at
all Schering-Plough facilities, specifics for PPE are not
provided on the SDS. Other operating procedures at each
site are used to communicate the use of appropriate PPE or
other handling guidance on a local level. Specific
questions associated with health hazards, handling, and
disposal are handled by appropriate safety and environmental
professionals at each site or at the corporate level.
Storage: Store in well sealed and secure containers in adequate rooms
at room temperature. Avoid substance residues outside the
containers.
Packaging of the substance and or preparation: double polyethylene bags within fibre board drums;
25 - 150 kg
Transport information
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Remarksopen allclose all
Marine transport (UN RTDG/IMDG)
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Air transport (UN RTDG/ICAO/IATA)
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Special provisions / remarks
- Remarks:
- Transport code: not classified.
Transport: Transport in well sealed suitable containers. The containers
should be secured against falling down. Label containers in
accordance with pertinent regulations.
SpecialProvisionsopen allclose all
Exposure controls / personal protection
Stability and reactivity
Danger other than fire: none known.
Chemical reaction with water: not to be expected.
Dust explosion: Explosive mixtures with dust possible but not to be expected
if handled under good industrial hygiene practices.
Dust explosion determined by test: N
Disposal considerations
Industry - Possibility of recovery/recycling: The test item is designed for use in closed systems as an
intermediate in the synthesis of an active pharmaceutical
ingredient. Therefore it is expected that it will be
consumed in the processes where it is employed. Hence the
need for recovery / recycling of the substance does not
apply in this case.
Industry - Possibility of neutralisation: Not applicable.
Industry - Possibility of destruction: controlled discharge: Not suitable for disposal in waste water treatment plants.
Industry - Possibility of destruction - incineration: Incineration is the preferred method of disposal.
Industry - Possibility of destruction - water purification: Not applicable.
Industry - Possibility of destruction - other: None.
Public at large - Possibility of recovery/recycling: Not applicable.
Public at large - Possibility of neutralisation: Not applicable.
Public at large - Possibility of destruction: controlled discharge: Not applicable.
Public at large - Possibility of destruction - incineration: Not applicable.
Public at large - Possibility of destruction - water purification: Not applicable.
Public at large - Possibility of destruction - others: None.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.