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EC number: 700-957-0 | CAS number: 1141852-17-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 Mar - 22 Apr 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,3-Propanediol, 2-methyl-, reaction products with ethenyltrimethoxysilane
- EC Number:
- 700-957-0
- Cas Number:
- 1141852-17-6
- Molecular formula:
- UVCB
- IUPAC Name:
- 1,3-Propanediol, 2-methyl-, reaction products with ethenyltrimethoxysilane
- Reference substance name:
- Reaction products of trimethoxy(vinyl)silane and 2-methylpropane-1,3-diol (2:5-6)
- IUPAC Name:
- Reaction products of trimethoxy(vinyl)silane and 2-methylpropane-1,3-diol (2:5-6)
- Details on test material:
- - Name of test material (as cited in study report): Y-15866
- Physical state: colourless liquid
- Analytical purity: 72%
- Lot/batch No.: 3710-10
- Expiration date of the lot/batch: 2013-07-16
- Stability under test conditions: stability unknown in PEG 300 (vehicle)
- Storage condition of test material: at room temperature (20 ± 5 °C) and light-protected
- Other: stability under storage conditions: yes
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: RccHan: WIST
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laboratories B.V., NM Horst, The Netherlands
- Age at study initiation: 10-11 weeks
- Weight at study initiation: 175.7-189.4 g
- Fasting period before study: animals were fasted prior to test substance administration for approximately 16 to 18 h. Food was provided again approximately 3 h after dosing.
- Housing: animals were housed in groups of 3 in Makrolon type-4 cages with wire mesh tops and standard softwood bedding (‘Lignocel’ J. Rettenmaier & Söhne GmbH & Co KG, Rosenberg, Germany).
- Diet: pelleted standard Provimi Kliba 3433 rat/mouse maintenance diet, batch no. 83/09 (Provimi Kliba AG, Kaiseraugst, Switzerland), ad libitum
- Water: community tap water from Füllinsdorf, Switzerland, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): 30-70
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 06 Apr 2010 (group 1) or 08 Apr 2010 (group 2) To: 20 Apr 2010 (group 1) 22 Apr 2010 (group 2)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: polyethylene glycol 300 (PEG 300)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20% (w/w)
- Amount of vehicle (if gavage): 10 mL/kg bw
- Justification for choice of vehicle: in a preliminary solubility test, the test substance was well dissolved in PEG 300.
- Lot/batch no.: S60502-099
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 in group 1 and group 2, respectively
- Control animals:
- other: not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animals were observed for clinical signs and mortality once before treatment, within the first 30 min and at approximately 1, 2, 3 and 5 h after treatment on Day 1. During the observation period, animals were observed twice daily for mortality and once daily for clinical signs. Body weights were recorded on Day 1 (prior to administration) and on Days 8 and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weights
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: experimental result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: LD50 cut-off according to OECD 423
- Mortality:
- No mortality occurred during the study period.
- Clinical signs:
- other: Slightly ruffled fur was observed in all 6 animals 2 h after test substance administration. The ruffled fur persisted with the same severity in 2 animals of group 2 at the 3 h reading. All 6 animals of groups 1 and 2 were free of clinical signs from the 5
- Gross pathology:
- No macroscopic findings were recorded at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results of a reliable acute toxicity study Y-15866 is not classified for acute oral toxicity.
- Executive summary:
The acute oral toxicity of Y-15866 was investigated in a GLP-conform study according to the acute toxic class method (OECD guideline 423). Two groups, each consisting of 3 female RccHan:WIST rats, were treated with Y-15866 diluted in PEG 300 as vehicle by single oral gavage administration at a limit dose of 2000 mg/kg bw. The animals were observed for clinical signs and mortality once before treatment, within the first 30 min and at approximately 1, 2, 3 and 5 h after treatment on Day 1. During the observation period of 14 days, animals were inspected twice daily for mortality and once daily for clinical signs. Body weights were recorded on Day 1 (prior to administration) and on Days 8 and 15. All animals were necropsied and examined macroscopically. No mortality occurred during the study period. Slightly ruffled fur was observed in all 6 animals 2 h after test substance administration. The ruffled fur persisted with the same severity in 2 animals at the 3 h reading. All 6 animals of groups 1 and 2 were free of clinical signs from the 5 h reading to the end of the study (on Day 15). The body weight of the animals was within the range commonly recorded for this strain and age. No macroscopic findings were recorded at necropsy. Based on these experimental results, the LD50 of Y-15866 was greater than 2000 mg/kg bw. According to the criteria of OECD guideline 423, the LD50 cut-off of Y-15866 may be considered to be greater than 5000 mg/kg bw.
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