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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Remarks:
- Read across data
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is taken from a secondary source
Data source
Reference
- Reference Type:
- other: Secondary source
- Title:
- SIDS Initial Assessment Report For SIAM 17
- Author:
- OECD-SIAM
- Year:
- 2 003
- Bibliographic source:
- OECD SIDS, SIAM, 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- 1983
- Principles of method if other than guideline:
- Acute inhalation of the given test sample was studies in Rats to determine LC50 value
- GLP compliance:
- not specified
- Test type:
- other: Standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-aminopropyltriethoxysilane
- EC Number:
- 213-048-4
- EC Name:
- 3-aminopropyltriethoxysilane
- Cas Number:
- 919-30-2
- Molecular formula:
- C9H23NO3Si
- IUPAC Name:
- 3-AMINOPROPYLTRIETHOXYSILANE
- Test material form:
- liquid
- Details on test material:
- Purity : = 98 - 100 % v/v
Constituent 1
- Specific details on test material used for the study:
- Not specified
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Rationale for alternative/additional species to rat (if applicable) No data Avaiable
- Source: Epona Associates, LLC
- Females (if applicable) nulliparous and non-pregnant: [yes/no] No data Avaiable
- Rationale for use of males (if applicable) No data avaiable
- Age at study initiation: Approximately 9 weeks old
- Weight at study initiation: No data avaiable
- Fasting period before study: No data avaiable
- Housing:No data avaiable
- Historical data:No data avaiable
- Diet (e.g. ad libitum): No data avaiable
- Water (e.g. ad libitum): Distill water
- Acclimation period: No data avaiable
- Microbiological status when known No data avaiable
- Method of randomisation in assigning animals to test and control groups No data avaiable
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data avaiable
- Humidity (%): No data avaiable
- Air changes (per hr): No data avaiable
- Photoperiod (hrs dark / hrs light): No data avaiable
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Mass median aerodynamic diameter (MMAD):
- 1.6 µm
- Geometric standard deviation (GSD):
- 2.19
- Remark on MMAD/GSD:
- Saturated vapors
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Solo-Sphere® nebulizer
- Exposure chamber volume: 120-liter exposure chamber
- Method of holding animals in test chamber: No data avaiable
- Source and rate of air (airflow): No data avaiable
- Method of conditioning air:No data avaiable
- System of generating particulates/aerosols: No data avaiable
- Method of particle size determination: No data avaiable
- Treatment of exhaust air: No data avaiable
- Temperature, humidity, pressure in air chamber: No data avaiable
TEST ATMOSPHERE
- Brief description of analytical method and equipment used: gas chromatographic analysis.
- Samples taken from breathing zone: No data avaiable
- Time needed for equilibrium of exposure concentration before animal exposure No data avaiable
VEHICLE
- Composition of vehicle (if applicable): No data avaiable
- Concentration of test material in vehicle (if applicable): No data avaiable
- Justification of choice of vehicle: No data avaiable
- Lot/batch no. (if required): No data avaiable
- Purity: No data avaiable
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: particle size distribution for the test material was determined with a cascade impactor
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): MMAD : 1.6 micrometers with a geometric standard deviation of 2.19
CLASS METHOD (if applicable)
- Rationale for the selection of the starting concentration: - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Remarks on duration:
- Not specified
- Concentrations:
- Not specified
- No. of animals per sex per dose:
- 5animals /sex/ dose
- Control animals:
- not specified
- Details on study design:
- Not Specified
- Statistics:
- standard deviation
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 7.35 mg/L air
- Based on:
- test mat.
- 95% CL:
- >= 6.65 - <= 9.52
- Exp. duration:
- 4 h
- Remarks on result:
- other: SD 0.92
- Mortality:
- LC50 was note at 7.35mg/L
- Clinical signs:
- other: During exposure, a dense fog was present within the animal chamber, preventing observation of the test animals. After exposure, slow righting reflex, labored breathing, hypoactivity, ataxia and discharge from the mouth, nose, and eyes were apparent.
- Body weight:
- All animal gain weight during study
- Gross pathology:
- Necropsy findings, included doses affected, severity and number of animals affected: No remarkable gross pathologic findings were seen.
Any other information on results incl. tables
Sex | Analytical Conc. (mg/l) | Mortality (No./total) | Mean body weight change (g) 0-7 days | Mean body weight change (g) 0-14 days | Overt toxicity | Number with remarkable gross pathology |
males | 7.35 (6.65-9.52) | 0/5 | 12 (8-17) | 28 (24-30) | On completion of exposure: slow righting reflex, labored breathing, hypoactivity, ataxia. Red encrustation around nose, mouth, or eyes that remained for 1 or 2 days. No abnormalities were detected on day 3. | 0/5 |
females | 7.35 (6.65-9.52) | 0/5 | 2 (2-8) | 9 (5-12) | On completion of exposure: slow righting reflex, labored breathing, hypoactivity, ataxia. Red encrustation around nose, mouth,or eyes that remained for 1 or 2 days. No abnormalities were detected on day 3. | 0/5 |
Table 1: Concentrations, mortality or evident toxicity
LC50 (males and females): > 7.35 mg/l (mean concentration)
Mean ethanol concentration was 3253 (standard deviation of 1621) ppm (equivalent to around 6.1 mg/l)
Applicant's summary and conclusion
- Interpretation of results:
- other: Not Classified
- Conclusions:
In a study, conducted in accordance with generally accepted scientific standards and probably according to GLP, male and female rats exposed to a 60% aqueous solution of the test substance achieved an LC50 of over 7.35 mg/l after four hours.- Executive summary:
The Read across sample was administered to all animals in five species/sex/doses. The body weight of all the surviving animals was found to be increased. On completion of exposure: slow righting reflex, labored breathing, hypoactivity, ataxia. Red encrustation around nose, mouth, or eyes that remained for 1 or 2 days. No abnormalities were detected on day 3. Necropsy findings, including doses affected, severity, and a number of animals affected: No remarkable gross pathologic findings were seen. Five rats were exposed for four hours to 7.35 mg/l of a 60% of test solution. The animals were observed during the subsequent 14-day post-exposure period. After exposure, slow righting reflex labored breathing, hypoactivity, ataxia, and discharge from the mouth, nose, and eyes were apparent. At 3 days, the animals were fully recovered Hence the test chemical cannot be classified according to CLP Criteria for classification.
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