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EC number: 267-012-8 | CAS number: 67762-34-9 This substance is identified by SDA Substance Name: C8-C18 and C18 unsaturated alkyl carboxylic acid zinc salt and SDA Reporting Number: 01-006-09.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 022
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Zinc dioctanoate
- EC Number:
- 209-156-6
- EC Name:
- Zinc dioctanoate
- Cas Number:
- 557-09-5
- Molecular formula:
- C16H30O4Zn
- IUPAC Name:
- zinc(II) octanoate
- Reference substance name:
- Zinc decanoate
- EC Number:
- 235-909-3
- EC Name:
- Zinc decanoate
- Molecular formula:
- C10H20O2.1/2Zn
- IUPAC Name:
- zinc(II) decanoate
- Reference substance name:
- Zinc dilaurate
- EC Number:
- 219-518-5
- EC Name:
- Zinc dilaurate
- Cas Number:
- 2452-01-9
- Molecular formula:
- C12H24O2.1/2Zn
- IUPAC Name:
- zinc(II) dodecanoate
- Reference substance name:
- Zinc dimyristate
- EC Number:
- 240-369-7
- EC Name:
- Zinc dimyristate
- Cas Number:
- 16260-27-8
- Molecular formula:
- C28H54O4Zn
- IUPAC Name:
- zinc(II) tetradecanoate
- Reference substance name:
- Zinc dipalmitate
- EC Number:
- 225-652-5
- EC Name:
- Zinc dipalmitate
- Cas Number:
- 4991-47-3
- Molecular formula:
- C16H32O2.1/2Zn
- IUPAC Name:
- zinc(II) hexadecanoate
- Reference substance name:
- Zinc distearate
- EC Number:
- 209-151-9
- EC Name:
- Zinc distearate
- Cas Number:
- 557-05-1
- Molecular formula:
- C18H36O2.1/2Zn
- IUPAC Name:
- zinc(II) octadecanoate
- Reference substance name:
- Zinc dioleate
- EC Number:
- 209-154-5
- EC Name:
- Zinc dioleate
- Cas Number:
- 557-07-3
- Molecular formula:
- C18H34O2.1/2Zn
- IUPAC Name:
- zinc(II) 9-octadecenoate
- Reference substance name:
- Zinc dilinoleate
- EC Number:
- 235-870-2
- EC Name:
- Zinc dilinoleate
- Cas Number:
- 13014-44-3
- Molecular formula:
- C36H62O4Zn
- IUPAC Name:
- zinc(II) 9,12-octadecdienoate
- Test material form:
- solid: bulk
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Constituent 6
Constituent 7
Constituent 8
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Species and strain : Sam;New Zealand White Rabbit
Microbiological grade : Specific Pathogen Free(SPF)
Sex : Female
Breeder : SAMTAKO BIO KOREA (105, Seorang-ro, Osan-si, Gyeonggi-do, Republic of Korea, 18100)
Supplier : Yeongbio (388, Dunchon-daero, Jungwon-gu, Seongnam-si, Gyeonggido, Republic of Korea, 13391)
Step Age(week old) Number of animals A range of body weight(g)
At receipt 10 4 1745.4~1815.2
At application 11 3 2018.4~2203.7
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- Group Dose volume (g) Number of animals Animal number
1 0.5 3 1~3
The 0.5 g of test substance was applicated per site in accordance with “Testing Guidelines for Studies of Chemicals, Chapter 5 Health impact test field, Section 3 Acute Dermal Irritation/Corrosion” National Institute of Environmental Research Notification. - Duration of treatment / exposure:
- 3 minutes, 1 hour, 4 hours
- Observation period:
- 24, 48, and 72 hours
- Number of animals:
- 3
- Details on study design:
- 3.2. Application of Test Substance
3.2.1. Justification for route of application
The dermal route was selected to investigate the skin irritation and corrosivity of the test substance.
3.2.2. Method
Onto the one site of back, 0.5 g/site of prepared test substance was applied to a small area of dermal and covered with a gauze patch moistened with a corn oil, which was held in place with non-irritating tape(Tegaderm, 3M_USA). The entire trunk of the animals was wrapped with elastic bandages(Coban, 3M). At the end of the exposure period, the dressing was removed and residual test substance was carefully washed away with corn oil. The adjacent area to the test site was served as a control.
3.2.2.1. Initial test (In vivo dermal irritation/corrosion test using one animal)
A single animal was administered sequentially first. The first patch was removed after 3 minutes of application, and the second patch was applied to a different site for 1 hour due to no serious dermal irritations observed after the first patch removal. No serious dermal irritation was observed after the second patch removal, and the third patch was applied to a different site for 4 hours.
3.2.2.2. Confirmatory test (In vivo dermal irritation test with additional two animals)
No skin corrosion was observed in the initial test. Therefore, the confirmatory test was conducted on two additional animals, each with one test substance patch, for an exposure period of 4 hours.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- No skin corrosion was observed after the first(applied for 3 minutes) and second(applied for 1 hour) and third(applied for 4 hours) application in the initial test conducted on one animal. Therefore, the confirmatory test with two animals were carried out. No skin corrosion was observed in all animals after the 4 hours application.
The skin irritation scores of erythema/eschar were calculated as “0.7”, “1.0”, “1.0”. The skin irritation scores of oedema was calculated as “0.0” in all animals.
The skin irritation scores for erythema/eschar and oedema calculated based on the results at 24, 48 and 72 hours are as follows.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- This study was conducted to confirm the Globally Harmonized System of Classification and Labelling of Chemical (GHS) category through the calculation of Skin Irritation Scores based on the acute dermal irritation and corrosivity of the test substance, Fatty acids, C8-18 and C18-unsatd., zinc salts, following a single skin application to female New Zealand White rabbits. Mortality, clinical signs and body weights, skin irritations and corrosivity were evaluated after the application of the test substance.
Mortality related to the test substance was not observed in all animals.
Slight exfoliation was observed in animal No. 2 and animal No. 3 in the confirmation test. This clinical sign was fully reversible on the 12 day after patch removal.
Body weight changes related to the test substance were not observed in all animals.
Corrosion was not observed in all animals up to 72 hours after application of the test substance.
The skin irritation scores of erythema/eschar were calculated as “0.7”, “1.0”, “1.0”. The skin irritation scores of oedema was calculated as “0.0” in all animals.
Therefore, the test substance was considered to be non-irritants and the 14-day observation period required to establish reversibility was not applied.
The above results show that when applying the test substance, Fatty acids, C8-18 and C18-unsatd., zinc salts to under the conditions of this study, considered to be “Not classified” according to the GHS category.
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