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EC number: 602-890-1 | CAS number: 122731-58-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- Nov 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- rac-N-(2,3-Dihydroxypropyl)-5-nitroisophthalamic acid
- EC Number:
- 602-890-1
- Cas Number:
- 122731-58-2
- Molecular formula:
- C11 H12 N2 O7
- IUPAC Name:
- rac-N-(2,3-Dihydroxypropyl)-5-nitroisophthalamic acid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Remarks:
- TOC Analysis
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
111.2 mg of ZK 39166 were dissolved in 1000 mL tap water under constant stirring for 3 hours. This solution was used as the test solution.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Source: Schering AG
- Age at study initiation (mean and range, SD): 0-24 h
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 283.6 mg/L
- Test temperature:
- control: 20.5 - 20.1 °C
ZK 39166: 21.4 - 20.4 °C - pH:
- control: 7.9 - 8.7
ZK 39166: 7.6 - 8.5 - Dissolved oxygen:
- control: 9.1 - 8.6 mg/L
ZK 39166: 8.4 - 8.5 mg/L - Nominal and measured concentrations:
- nominal : 100 mg/L
measured: 94.8 mg/L (mean 0/48 h) - Details on test conditions:
- TEST SYSTEM
20 Daphnia were used tor the test solution and also for the control group, randomly distributed into blocks of five. Labelled 100 mL test vessels were used and filled with 50 mL of the test solution and the dilution water (control group) including 5 mL of culturing water with the Daphnia, thus giving a concentration of 100 mg/L. The test was performed with 4 replicates of the test solution and the dilution water control with 5 Daphnia in each vessel. One additional test vessel was used without Daphnia for the measurements of pH, temperature and oxygen content in the dilution water control and in the test solution. The test started when the animals were added to the previously prepared test solution. The Daphnia were exposed to the test concentration and to the dilution water control for a period of 48 hours under static conditions. The light/dark rhythm was adjusted to 12 hours/12 hours.
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 (48 hours) of Nip-Monoamide to Daphnia magna is higher than 100 mg/L.
- Executive summary:
The purpose of this study was to determine the acute toxicity (immobilization, EC50/48 hours) of the compound Nip-Monoamide (ZK 39166) to Daphnia magna in a Limit-test. The study was conducted in agreement with the test guideline of the OECD, no. 202, adopted: 04 Apr. 84, and the EEC Directive 92/69, Part C2, 1992. 20 Daphnia were used tor the test solution of Nip-Monoamide and 20 for the control group. The Daphnia were exposed to the test substance and the dilution water for a period of 48 hours under static conditions in a limit-test. Immobilization was recorded at 24 hours and 48 hours. The test concentration was 100 mg/L nominal (equivalent to 94.8 mg/L measured as TOC). One immobilized Daphnia was observed in the test solution at 48 hours. Accordingly, the EC50 (48 hours) of Nip-Monoamide to Daphnia magna is higher than 100 mg/L.
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