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Diss Factsheets
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EC number: 421-750-9 | CAS number: 57280-22-5 TRIOXABICYCLOOCTAN; TRIOXABICYCLOOCTANE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Remarks:
- expert statement
- Type of information:
- other: expert statement based on physico-chemical and toxicological data
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Reason / purpose for cross-reference:
- reference to other study
- Reason / purpose for cross-reference:
- reference to other study
- Reason / purpose for cross-reference:
- reference to other study
- Reason / purpose for cross-reference:
- reference to other study
- Reason / purpose for cross-reference:
- reference to other study
- Reason / purpose for cross-reference:
- reference to other study
- Reason / purpose for cross-reference:
- reference to other study
- Reason / purpose for cross-reference:
- reference to other study
- Reason / purpose for cross-reference:
- reference to other study
- Objective of study:
- absorption
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- expert statement based on physico-chemical and toxicological data according to REACH Guidance R.7
- GLP compliance:
- no
- Details on absorption:
- At >1000 g/L at 20°C, ZK 39294 is readily soluble in water and not very lipophilic, which is reflected in the octanol/water partition coefficient (log Pow) of -0.07 at 25°C.
Due to this low fat solubility, absorption of the substance through the outer skin and mucous membranes is considered to be rather low.
The substance is expected to be absorbed unchanged from the gastrointestinal tract, however only to a rather small extent. This is indicated by the results of the 28-day study in rats, in which no findings were reported up to 40 mg/kg daily. Even the daily administration of 200 mg/kg over 4 weeks caused only minor impairment of the general condition, which indicates that the limit of general tolerability has been reached.
The test results for mutagenicity are negative. It is assumed that either rapid deactivation of the epoxide function by epoxide hydrolase or the absence of cellular absorption is responsible for this result.
The vapor pressure with a value of 30.5 Pa (20°C) is rather high, Thus, absorption by inhalation must be expected.
Because of its low lipophilicity, the substance will most likely be distributed primarily in the extracellular space and hardly in organs and tissues.
Because of the small molecular size and the high hydrophilicity, predominantly renal excretion is to be expected. In principle, possible metabolic reactions, such as hydroxylation and various conjugations may further increase the water solubility and subsequently stimulating the renal excretion.
No toxicologically significant systemic effects of ZK 39294 after single or multiple oral or single dermal administration were detected. These results indicate either a lack of adverse effects based on low bioavailability or a good systemic availability and tolerability, the latter one can be explained by a rapid deactivation of the epoxide function in first place. - Conclusions:
- Treatment with the test item does not result in a major impairment of the general condition in the available toxicological data. These results in correlation with its physico-chemical properties rather indicate a reduced bioavailability via the gastrointestinal tract and the skin. However, a rapid metabolism due to its hydrophilic structure, i.e. the epoxid moiety can also not be excluded. Based on the high vapour pressure also absorption via inhalation may be possible.
Reference
Description of key information
expert statement based on physico-chemical and toxicological data.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 100
Additional information
Treatment with the test item does not result in a major impairment of the general condition in the available toxicological data. These results in correlation with its physico-chemical properties rather indicate a reduced bioavailability via the gastrointestinal tract and the skin. However, a rapid metabolism due to its hydrophilic structure, i.e. the epoxid moiety can also not be excluded. Based on the high vapour pressure also absorption via inhalation may be possible.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.