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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Boiling point
Administrative data
Link to relevant study record(s)
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 December 2020 - 19 February 2021
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Well documented study performed according to OECD 103 guideline and EU method A.2, under GLP and without deviation
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling Point)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 2018-11-15
- Type of method:
- differential scanning calorimetry
- Boiling pt.:
- 290 °C
- Atm. press.:
- 101.3 kPa
- Remarks on result:
- other: First determination - Corrected value following Sydney-Young equation
- Boiling pt.:
- 288.3 °C
- Atm. press.:
- 101.3 kPa
- Remarks on result:
- other: Second determination - Corrected value following Sydney-Young equation
- Boiling pt.:
- 290.4 °C
- Atm. press.:
- 101.3 kPa
- Remarks on result:
- other: Third determination - Corrected value following Sydney-Young equation
- Boiling pt.:
- 288.7 °C
- Atm. press.:
- 98.5 kPa
- Decomposition:
- no
- Remarks on result:
- other: First determination
- Boiling pt.:
- 287 °C
- Atm. press.:
- 98.5 kPa
- Decomposition:
- no
- Remarks on result:
- other: Second determination
- Boiling pt.:
- 289.1 °C
- Atm. press.:
- 98.6 kPa
- Decomposition:
- no
- Remarks on result:
- other: Third determination
- Boiling pt.:
- ca. 290.2 °C
- Atm. press.:
- ca. 101.3 kPa
- Remarks on result:
- other: Corrected value with the Sydney Young equation (mean of the first and third determination)
- Conclusions:
- After correction using the Sydney Young equation, the initial boiling point of the substance was determined as 290.2°C at 101.3 kPa (mean of 290.0°C for the first determination and 290.4°C for the third determination).
- Executive summary:
A study was performed to determine the boiling point of the test item using the Differential Scanning Calorimetry (DSC). The method followed was designed to be compliant with Regulation EC No. 440/2008 Method A.2. and OECD Test Guideline No. 103, "Boiling Point" (1995).
In this method, two crucibles, with pierced lid, were put in the apparatus furnace under inert atmosphere (helium) at atmospheric pressure. One crucible contained the test item, the other was empty and considered as the reference. A specific temperature program was applied.
The crucibles were linked to two thermocouples fixed on the TG-DSC sample carrier. Heat flow differences between the two crucibles and mass variation were recorded on a thermogram.
A cooling system using liquid nitrogen allowed experiments with low temperatures down to -120°C.Three trials were conducted and corresponding thermograms were obtained, giving us the following results:
Trial
Initial boiling point
Ambient pressure
Corrected (normal) boiling point
1
288.7 °C
98.5 kPa
290.0 °C
2
287.0 °C
98.5 kPa
288.3 °C
3
289.1 °C
98.5 kPa
290.4 °C
Both melting and boiling occur as a single peak. The melting point and initial boiling point values from trials 1 and 3 respect validity criteria (no more than 0.5°C of difference up to 326.85°C).
Moreover, the melting point of the Indium respects the checking cards limits (156.4°C for a reference value of 156.6°C) so as its enthalpy (29.16 J/g for a reference value of 28.6 J/g).After correction using the Sydney Young equation, the initial boiling point of the substance was determined as 290.2°C at 101.3 kPa (mean of 290.0°C for the first determination and 290.4°C for the third determination).
Reference
Pre-study:
Peaks assigned to the boiling of the substance was observed and measurement was stopped at 340°C (Figure 1).
The initial boiling point of the substance was observed at 285.7°C.
A corresponding mass loss was observed between the beginning and the end of the boiling peak.
Temperatures corresponding to these peaks were used to create the following temperature program:
Temperature program:
Step | Initial temperature (°C) | Final Temperature (°C) | Heating rate (°C/min) | Duration (min) | Furnace atmosphere | Rate* (mL/min) | Liquid nitrogen cooling |
1 | 20 | -120 | -10 | 14 | He | 60 | YES |
2 | -120 | -120 | 0 | 10 | He | 60 | YES |
3 | -120 | 350 | 10 | 47 | He | 60 | NO |
*Gas injection rate in the furnace.
First Determination:
Mass taken: 13.81 mg
Temperature calibration file: CAN03-Al-He-10K-04
Sensitivity calibration file: CAN03-Al-He-10K-04
File name: DSC 20-036 01
The thermogram of the first determination is shown in Figure 2.
Results: Initial boiling point was observed at 288.7°C (onset temperature of the peak) and a mass loss of 13.743 mg (99.5%) was observed between the beginning and the end of the boiling peak.
The crucible was visually checked after the determination: By opening the crucible, no test item left in the crucible and no sign of decomposition was observed.
Atmospheric pressure: 98.5 kPa.
Second Determination:
Mass taken: 13.05 mg
Temperature calibration file: CAN03-Al-He-10K-04
Sensitivity calibration file: CAN03-Al-He-10K-04
File name: DSC 20-036 02
The thermogram of the second determination is shown in Figure 3:
Results: Initial boiling point was observed at 287.0°C (onset temperature of the peak) and a mass loss of 12.811 mg (98.2%) was observed between the beginning and the end of the boiling peak.
The crucible was visually checked after the determination: By opening the crucible, no test item left in the crucible and no sign of decomposition was observed.
As the boiling point values of determinations 1 and 2 did not respect validity criteria (no more than 0.5°C of difference up to 326.85°C), a third determination was performed.
Atmospheric pressure: 98.5 kPa.
Third Determination:
Mass taken: 13.74 mg
Temperature calibration file: CAN03-Al-He-10K-04
Sensitivity calibration file: CAN03-Al-He-10K-04
File name: DSC 20-036 03
The thermogram of the third determination is shown in Figure 4:
Results: Initial boiling point was observed at 289.1°C (onset temperature of the peak) and a mass loss of 13.737 mg (100.0%) was observed between the beginning and the end of the boiling peak.
The crucible was visually checked after the determination: By opening the crucible, no test item left in the crucible and no sign of decomposition was observed.
Atmospheric pressure: 98.6 kPa.
Sydney-Young Correction:
In case of small pressure deviations the boiling temperature at standard pressure can be calculated following the equation of Sydney-Young:
Tn = T + (ƒ x Δp)
With
Tn = boiling point at 101.325 kPa in K
T = measured boiling point in K
ƒ = correction factor (tabulated value)
Δp = (101.325 – p) kPa
P = measured atmospheric pressure in kPa
Correction factor is obtained by regressing the values from the following table:
Temperature | ƒT (K/kPa) |
323.15 | 0.26 |
348.15 | 0.28 |
373.15 | 0.31 |
398.15 | 0.33 |
423.15 | 0.35 |
448.15 | 0.37 |
473.15 | 0.39 |
498.15 | 0.41 |
523.15 | 0.44 |
548.15 | 0.45 |
573.15 | 0.47 |
The corrected values at 101.3 kPa following Sydney-Young equation were determined to be 290.0°C for the first determination, 288.3°C for the second determination and 290.4°C for the third determination.
Description of key information
Bp: 290 ºC at ca. 101.3 kPa, OECD TG 103
Key value for chemical safety assessment
- Boiling point at 101 325 Pa:
- 290 °C
Additional information
A study was performed to determine the boiling point of the test item using the Differential Scanning Calorimetry (DSC). The method followed was designed to be compliant with Regulation EC No. 440/2008 Method A.2. and OECD Test Guideline No. 103, "Boiling Point" (1995).
After correction using the Sydney Young equation, the initial boiling point of the substance was determined as 290.2°C at 101.3 kPa (mean of 290.0°C for the first determination and 290.4°C for the third determination).
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