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EC number: 485-320-2 | CAS number: 221667-31-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 Feb 2004 - 16 May 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Qualifier:
- according to guideline
- Guideline:
- EPA Guideline Subdivision N 161-1 (Hydrolysis)
- Qualifier:
- according to guideline
- Guideline:
- other: Canada PMRA DACO Number 8.2.3.2
- Qualifier:
- according to guideline
- Guideline:
- other: Japan MAFF Guideline, 12 Nousan 8147
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- yes
- Analytical monitoring:
- yes
- Buffers:
- - pH: 4
- Type and final molarity of buffer: Acetate, 0.01 M
- Composition of buffer: Approximately 180 mL of sodium acetate (0.01 M in water) was added to 1000 mL of 0.01 M acetic acid to obtain pH 4.
- pH: 7
- Type and final molarity of buffer: Tris(hydroxymethyl)aminomethane, 0.01 M
- Composition of buffer: Approximately 105 mL of 0.1 M tris(hydroxymethyl)aminomethane was added to 1 000 mL of 0.01 M HCI to obtain pH7.
- pH: 9
- Type and final molarity of buffer: Borate, 0.01 M
- Composition of buffer: Approximately 40 mL of 0.1 M NaOH was added to 1 000 mL of 0.01 M boric acid to obtain pH 9. - Details on test conditions:
- Test 1: 50 ±0.1 °C
Test 2: 25 ±0.1 °C
TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: 20 mL amber glass serum vial equipped with a Teflon lined septum and crimp cap.
- Sterilisation method: Autoclave
- Lighting: Continuous darkness
- Details of traps for volatile, if any: None. No volatiles were formed
- If no traps were used, is the test system closed: yes, system is closed.
- Is there any indication of the test material adsorbing to the walls of the test apparatus?: No
TEST MEDIUM
- Volume used/treatment: 1 0 mL of buffer treated with 0.05 mL of application solution post-autoclaving
- Identity and concentration of co-solvent: ACN, <0.5% - Duration:
- 5 d
- pH:
- 4.01
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.99 - 1.01 µg/L
- Duration:
- 5 d
- pH:
- 7.14
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.99 - 1.01 µg/L
- Duration:
- 5 d
- pH:
- 9.16
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.99 - 1.01 µg/L
- Duration:
- 30 d
- pH:
- 4
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.95 - 0.97 µg/L
- Duration:
- 30 d
- pH:
- 7
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.95 - 0.97 µg/L
- Duration:
- 30 d
- pH:
- 9
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.95 - 0.97 µg/L
- Number of replicates:
- 2
- Positive controls:
- yes
- Remarks:
- Pond water from Stilwell, KS (Bayer Research Park), was used as a positive control
- Negative controls:
- no
- Remarks:
- No other control substances were used in this study
- Preliminary study:
- The average radioactivity balance for Test 1 was 101.7% (range = 98.7 to 105.4%), 102.0% (range = 98.3 to 105.8%, and 102.0% (range = 98.2 to 105.7%) of the applied radioactivity at pH 4, 7 and 9, respectively. Most of the applied radioactivity was associated with the parent compound at test termination in the pH 4, 7 and 9 buffer solutions. Two minor transformation products were formed at a combined maximum of 1.3% (Day 4; pH 4), 1.9 (Day 4; pH 7), and 1.8% (Day 0; pH 9) of the applied radioactivity.
- Transformation products:
- no
- Details on hydrolysis and appearance of transformation product(s):
- - Formation and decline of each transformation product during test: No attempt was made to identify the minor transformation products observed in the study since they comprised <1.9% of the applied radioactivity at any interval in both tests.
- Pathways for transformation: AE 0001789 was stable in all buffers tested with no major transformation products observed. - % Recovery:
- 100
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- other:
- Remarks:
- % Recovery: 101.3
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- other:
- Remarks:
- % Recovery: 101.3
- % Recovery:
- 97.5
- pH:
- 4
- Temp.:
- 25 °C
- Duration:
- 30 d
- % Recovery:
- 98.8
- pH:
- 7
- Temp.:
- 25 °C
- Duration:
- 30 d
- % Recovery:
- 97.2
- pH:
- 9
- Temp.:
- 25 °C
- Duration:
- 30 d
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Validity criteria fulfilled:
- not applicable
Reference
AE 0001789 did not degrade significantly in pH 4, 7, and 9 buffer solutions. No major transformation products were formed in this study. Minor degradates did not exceed a combined 1.9% of the applied radioactivity.
The DT50 values for the degradation of AE 0001789 were not calculated for pH 4, 7 and 9 because of limited degradation. AE 0001789 is hydrolytically stable at pH 4, 7 and 9.
Description of key information
DT50 > 1 year (50°C and 25°C at pH 4, 7, 9; OECD 111)
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
One OECD 111 study is available for the substance Cyprosulfamide (M-279728-01-1). The test substance did not hydrolyse significantly in pH 4, 7, and 9 sterile buffer solutions at 25 and 50 °C. No major transformation products were formed in this study. Minor degradation products did not exceed a sum of 1.9% of the applied radioactivity. The DT50 values for the hydrolytic degradation of the substance were not calculated for pH 4, 7 and 9 because of limited degradation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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