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EC number: 236-211-1 | CAS number: 13236-02-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- 1. Preparation of test substance
The test substance was calibrated according to purity (100%). The method of preparation was selected to maximize the solubility of the test substance under specific test exposure conditions. Test substance of 0.05000 and 0.05002 g was dissolved in M4 media as solvent to make the test stock solution. The test substance was prepared in 500 mL capacity glass volumetric flask with 500 mL of dilution agent. Then the volumetric flask was stirred at 200 rpm with a stir bar (38 mm) was added. Test substances were prepared before 48 hours prior to the treatment at room temperature. After stirring for 48 hours, the test stock solution was filtered through 0.45 μm PVDF filter.
2. Analysis of test substance
The analyses of test substance in the test water was not conducted because the analytical method of test substance could not be established. - Analytical monitoring:
- not specified
- Vehicle:
- yes
- Details on test solutions:
- The test substance was calibrated according to purity (100%). The method of preparation was selected to maximize the solubility of the test substance under specific test exposure conditions. Test substance of 0.05000 and 0.05002 g was dissolved in M4 media as solvent to make the test stock solution. The test substance was prepared in 500 mL capacity glass volumetric flask with 500 mL of dilution agent. Then the volumetric flask was stirred at 200 rpm with a stir bar(38 mm) was added. Test substances were prepared before 48 hours prior to the treatment at room temperature. After stirring for 48 hours, the test stock solution was filtered through 0.45 μm PVDF filter.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- 1. Age
Less than 24 hours after birth
2. Selection of the test species
The water flea (Daphnia magna) is recommended in “OECD guideline for the testing of chemicals 202”, and was selected for this test because this species have a plenty of comparable toxicological data.
3. Environmental condition
The daphnia were bred in 1 L cylinder glass bath. The temperature of breeding water is maintained within the range of 18~22℃ and photo periods are 16 hours light and 8 hours darkness.
4. Feeding
Feeds were supplied once a day: chlorella vulgaris
5. Breeding water and water quality
The water quality was analyzed for total hardness and alkalinity of the test water was measured by hardness meter and alkalinity meter. - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- 24 and 48 hrs
- Hardness:
- 190 mg/L as CaCO3
- Test temperature:
- 20.7℃
- pH:
- pH 7.98
- Dissolved oxygen:
- 7.87 mg/L
- Nominal and measured concentrations:
- 100.0 mg/L(nominal concentration)
- Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOELR
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Details on results:
- There was no immobility observed in any of the daphnia exposed to control group and 100.0 mg/L of test solution at 48 hours. No abnormal behavior was observed in control and treatment groups during a limit test.
- Reported statistics and error estimates:
- EC50 and 95% confidence limits were not statistically calculated, because no immobility was observed after 48 hours in the highest concentration, 100.0 mg/L. Also, effects concentrations in tests based upon WSF (Water Soluble Fraction) was able to calculate from the loading rates and are identified as either EL50 values. NOEC was determined as the highest concentration causing no abnormal behavior and immobility and becomes the NOELR (No Observable Effect Loading Rate). The methods used to determine EL50 and NOELR values was the same as those used to determine EC50 and NOEC values.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The 48 hours EL50 value of 1,2,3-tris(2,3-epoxypropoxy)propane to Daphnia magna was determined to be higher than 100.0 mg/L, NOELR was 100.0 mg/L. The EL50 and NOELR were based on nominal concentration (loading rate).
Reference
Description of key information
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- > 100 mg/L
Additional information
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