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EC number: 401-700-2 | CAS number: 3100-36-5 CYCLOHEXADECENON; CYCLOHEXADECENONE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1981
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- A mixture of cis- and trans-cyclohexadec-8-en-1-one
- EC Number:
- 401-700-2
- EC Name:
- A mixture of cis- and trans-cyclohexadec-8-en-1-one
- Cas Number:
- 3100-36-5
- Molecular formula:
- C16H28O
- IUPAC Name:
- (8E)-cyclohexadec-8-en-1-one; (8Z)-cyclohexadec-8-en-1-one
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- SPF
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Females nulliparous and non-pregnant: Yes
- Rationale for use of males: Both sexes were investigated
- Age at study initiation: Not specified
- Weight at study initiation: Mean body weights of 205 g
- Fasting period before study: 16 hours before test started
- Housing: In groups of 5 males and 5 females in single cages
- Diet Ad libitum (laboratory standard diet Altromin)
- Water: Ad libitum
- Acclimation period: Not specified
- Microbiological status when known: SPF
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/-1
- Humidity (%): 45-55
- Air changes (per hr): Not specified
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From day 0 to day 15
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- The test item has been used undiluted after warmed up in a waterbath.
- Details on oral exposure:
- DOSAGE PREPARATION: The test item has been used undiluted after warmed up in a waterbath.
- Doses:
- 5,000 mg/kg bw and 10,000 mg/kg bw
- No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 24 hours, 48 hours, 7 days and 14 days after dosing
- Necropsy of survivors performed: Yes
- Clinical signs including body weight: Appearance and behavior, reflexes, coat, cutaneous turgor, mucosae, faeces, body weights, food and water uptake, acute symptoms - Statistics:
- LD50 oral according to Litchfield & Wilcoxon. 24-hours and 14-days LD50 slope function not measurable.
Results and discussion
- Preliminary study:
- Doses were chosen on account of an informational pre-test.
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- No mortality occured
- Clinical signs:
- other: In all dosage groups the preparation did not cause any remarkable symptoms.
- Gross pathology:
- Slight intestinal hyperaemia in 5 of 10 animals in the highest dosage in final autopsy could be
observed, possibly due to volume. No other macroscopical pathological changes could be observed. - Other findings:
- No other findings were observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute oral toxicity study in rats according to OECD guideline 401, the LD50 was higher than 10,000 mg/kg bw.
- Executive summary:
In an acute oral toxicity study according to OECD guideline 401 and GLP, the test item has been tested after one oral application in the rat. Under the conditions of the experiment, the following results have been determined: The 24 hour-LD50 and 14 days LD50 of the product has been found at higher than 10,000 mg/kg body weight. Body weights did not point to incompatibility. Clinical picture did not show alterations to normal findings. In the final autopsy, no clear anatomic pathological changes occurred. Slight intestinal hyperemia in 5 out of 10 animals in the highest dosage could be observed. Therefore, the product can be considered as nearly harmless (nontoxic).
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