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EC number: 213-497-6 | CAS number: 959-26-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The toxicity of bis(2-hydroxyethyl) terephthalate (BHET; CAS No. 959-26-2) was assessed using information on the terephthalic acid, and the ethylene glycol transformation products.
Based on a conservative prediction, the 48h daphnid EC50 of BHET is predicted to be > 1530 mg/L.
Based on a conservative prediction, the 96h algae ErC50 of BHET is predicted to be > 1530 mg/L.
Based on a conservative prediction, the 96h fish LC50 of BHET is predicted to be > 1530 mg/L.
Based on a conservative prediction, the 3h ASRIT EC50 of BHET is predicted to be > 2131 mg/L.
The Chemical Safety Assessment according to Annex I indicates that there is no need to investigate further the effects on aquatic organisms.
Additional information
Information on the source substances is considered to be directly applicable to an equivalent molar amount of the target substance.
Short-term toxicity on invertebrates (REACH Annex VII 9.1.1)
The short-term toxicity on invertebrates of terephthalic acid was assessed in Daphnia magna in a GLP-compliant study according to OECD 202. The reported 48h EC50 was greater than 1 000 mg/L or greater than 6.0 mmol/L. The toxicity of ethylene glycol to Daphnia magna was assessed in a study similar to OECD 202 which pre-dates GLP. The reported 24h LC50 was greater than 10 000 mg/L or greater than 161.1 mmol/L. The conservative 48h EC50 of BHET was predicted to be greater than 6.0 mmol/L or greater than 1 530 mg/L.
Growth inhibition study on aquatic plants (REACH Annex VII 9.1.2)
The effects on the growth of aquatic plants for terephthalic acid was assessed in Desmodesmus subspicatus in a GLP-compliant study according to OECD 201. The reported 96h ErC50 was greater than 1 000 mg/L or greater than 6.0 mmol/L. The ability of ethylene glycol to inhibit the growth of Raphidocelis subcapitata was assessed in an US EPA/600/4-89/01 Short-term method for estimating chronic toxicity of effluents and receiving waters to freshwater organisms. The reported 96h IC50 was 10 940 mg/L or 176.3 mmol/L. The conservative 96h ErC50 of BHET was predicted to be greater than 6.0 mmol/L or greater than 1 530 mg/L.
Short-term toxicity on fish (REACH Annex VIII 9.1.3)
The short-term toxicity on fish of terephthalic acid was assessed in Leuciscus idus melantotus (Golden Orfe) in a GLP-compliant study according to OECD 203. No mortalities or behavioural changes were noted at any concentration during the study. The reported 96h LC50 was greater than 1 000 mg/L or greater than 6.0 mmol/L. The toxicity of ethylene glycol to Carassius auratus (goldfish) was assessed in a study similar to OECD 203 which pre-dates GLP. The reported 24h LC50 was greater than 5 000 mg/L or greater than 80.6 mmol/L. The conservative 96h LC50 of BHET was predicted to be greater than 6.0 mmol/L or greater than 1 530 mg/L.
Activated sludge respiration inhibition (REACH Annex VIII 9.1.4)
A GLP-compliant OECD 209 study was conducted with terephthalic acid. The respiration rate of activated sludge was not inhibited at saturated concentrations during the range finding study. The reported 16d EC50 was 1 392.8 mg/L or 8.4 mmol/L. The activated sludge respiration inhibition of ethylene glycol was assessed according to DIN 38412-8 using Pseudomonas putida. The 16-hour toxic threshold concentration (TTC), comparable with an EC5, was reported to be greater than 10 000 mg/L or 161.1 mmol/L. The information on the source substances is for longer exposure times than the 3-hour exposure period required by OECD 209 and would be a conservative estimate of the 3-hour respiration inhibition concentration. The conservative 3h EC50 of BHET was predicted to be greater than 8.4 mmol/L or greater than 2 131 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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