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EC number: 205-440-9 | CAS number: 140-90-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Sodium hydroxide is both reagents used in the manufacture of sodium O-ethyl dithiocarbonate . Therefore, sodium hydroxide need to be considered in the assessment of sodium O-ethyl dithiocarbonate
Data source
Reference
- Reference Type:
- publication
- Title:
- Identification of contact allergens: the mouse ear sensitization assay.
- Author:
- Descotes, J.
- Year:
- 1 988
- Bibliographic source:
- J Toxicol -Cut & Ocular Toxicol 7:263-272
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Mouse ear swelling test. Substance applied to mouse ear with adjuvant with measure of subsequent swelling used to indicate hypersensitivity.
- GLP compliance:
- not specified
- Type of study:
- mouse ear swelling test
- Justification for non-LLNA method:
- An ear swelling study was used to examine the skin sensitising potential of ethanol. Ethanol was applied twice on the right ear after an induction procedure involving two scapular subcutaneous injection of adjuvant and multiple topical ethanol applications to the abdomen over a period of 14 days.
Test material
- Reference substance name:
- Sodium O-ethyl dithiocarbonate
- EC Number:
- 205-440-9
- EC Name:
- Sodium O-ethyl dithiocarbonate
- Cas Number:
- 140-90-9
- Molecular formula:
- C3H6OS2.Na
- IUPAC Name:
- sodium (ethoxymethanethioyl)sulfanide
- Test material form:
- solid: bulk
- Details on test material:
- SEX /sodium O-ethyl dithiocarbonate is produced by the reaction of an ethyl alcohol with sodium hydroxide to form alcoholate and subsequently adding carbon disulfide to form SEX/ sodium O-ethyl dithiocarbonate.
SEX /sodium O-ethyl dithiocarbonate contains Ethanol/ethyl alcohol (CAS number 64-17-5) and sodium hydroxide (CAS number 1310-73-2) which are an integral part of the substance.
Ethanol/ethyl alcohol (CAS number 64-17-5) and sodium hydroxide (CAS number 1310-73-2) are both reagents used in the manufacture of SEX /sodium O-ethyl dithiocarbonate. Therefore, Ethanol/ethyl alcohol (CAS number 64-17-5) and sodium hydroxide (CAS number 1310-73-2) need to be considered in the assessment of SEX /sodium O-ethyl dithiocarbonate.
CAS name: ethyl alcohol
EC / List name: Ethanol
IUPAC name: ethanol
EC / List no.: 200-578-6
CAS no.: 64-17-5
CAS name: sodium hydroxide
EC / List name: Sodium hydroxide
IUPAC name: sodium hydroxide
EC / List no.: 215-185-5
CAS no.: 1310-73-2
1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male/female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: IFFA-CREDO, L'Arbresle, France
- Age at study initiation: 6 - 8 weeks
- Housing: polyethylene cages
- Food and water ad libitum
- Acclimation period: 7 days
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal and epicutaneous
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- neat
Challengeopen allclose all
- Route:
- intradermal and epicutaneous
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- neat
- No. of animals per dose:
- 23
- Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
Anaesthetised animals received subcutaneous injection of 0.05ml of ethanol and complete Freund' adjuvant (CFA) into scapular region plus topical application to shaved abdomen (amount not specified - referred to as day 0).
B. CHALLENGE EXPOSURE
- No. of exposures: 7
- Day(s) of challenge: days 3, 5, 7, 10, 12 and 14 and 27
- Topical application on the shaved abdomen (amount not specified) on days above and a 2nd subcutaneous injection of CFA (0.05ml) on day 7 only.
OTHER: Mice were allowed to rest between days 14-26. On day 26, the thickness of the ear was measured before another topical application of the test substance to both sides of the ear. Ear thickness was measured again on days 27 and 28 (24 and 48 hours later). Thickness measurements were carried out with a mobile-disk dial caliper with an accuracy of 0.01mm. - Positive control substance(s):
- yes
- Remarks:
- Penicillin, paraphenylene diamine and nickel chloride
Results and discussion
In vivo (non-LLNA)
Results
- Remarks on result:
- no indication of skin sensitisation
Any other information on results incl. tables
Measurements of 94 untreated mice showed an ear thickness of 0.214 mm with a typical variation of 0.002 mm.
Results on sensitisation and challenge with ethanol:
Sex |
Number |
Before |
24 hour |
48 hour |
Male |
9 |
26.94 +/-1.02 |
27.22 +/-1.58 (101.0%) |
27.78 +/-1.86 (103.1%) |
Female |
10 |
24.30 +/-1.38 |
24.95 +/-1.44 (102.7%) |
23.55 +/-1.46 (96.9%) |
Known moderate and strong sensitizers applied as controls produced significant swelling in this study.
Induction and challenge with the three positive controls all produced statistically significant increases in ear thickness.
Applicant's summary and conclusion
- Interpretation of results:
- other: not sensitising
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Classification: not sensitizing.Ethanol/ Ethyl Alcohol is both reagents used in the manufacture of sodium O-ethyl dithiocarbonate . Therefore, Ethanol/ Ethyl Alcohol need to be considered in the assessment of Reaction mass of sodium O-ethyl dithiocarbonate
- Executive summary:
An ear swelling study was used to examine the skin sensitising potential of ethanol. Ethanol was applied twice on the right ear after an induction procedure involving two scapular subcutaneous injection of adjuvant and multiple topical ethanol applications to the abdomen over a period of 14 days. The degree of contact hypersensitivity is deduced from easr swelling measured 24 and 48 hours after application. Ethanol was found not to cause any statistical increase in ear swelling, in contrast to 3 positive controls which all caused a statistically significant increase.
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