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EC number: 443-870-0 | CAS number: 163520-33-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 Feb - 09 Mar 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- Current version adopted in 2017
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- Guideline in place during study conduct: adopted in 1987
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-2 (Acute Dermal Toxicity)
- Version / remarks:
- Adopted in 1988
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Agricultural chemicals, Laws and Regulations Japan, MAFF (p. 20 - 21)
- Version / remarks:
- 1985
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 443-870-0
- EC Name:
- -
- Cas Number:
- 163520-33-0
- Molecular formula:
- C18H17NO3
- IUPAC Name:
- ethyl 5,5-diphenyl-4,5-dihydro-1,2-oxazole-3-carboxylate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- Hoe: WISKf(SPF71)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: SPF breeding colony, Hoechst AG, Kastengrund, Germany
- Females nulliparous and non-pregnant: not specified
- Age at study initiation: males: approx. 8 weeks, females: approx. 11 weeks
- Body weight at study initiation: males: 225 g (mean), 220 - 230 g (range); females: 227 g (mean), 222 - 229 g (range)
- Housing: single housed in Makrolon cages (Type 3) on soft wood granulate
- Diet: Altromin 1324 rat diet (Altromin GmbH, Lage/Lippe, Germany), ad libitum
- Water: tap water in drinking water quality, ad libitum
- Acclimation period: at least 1 day
- Microbiological status : SPF bred animals
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): 50 ± 20
- Air changes: fully air-conditioned rooms
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 23 Feb 1994 To: 09 Mar 1994
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: sesame oil
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 30 cm² shaved skin of the dorsal area of the trunk
- Type of wrap if used: The treated skin area was covered with a porous gauze and an aluminium foil (6 x 8 cm), which was held in place with an elastic plaster bandage fixed around the animal's body in order to avoid evaporation of the test substance and ingestion of the test substance by the animals.
REMOVAL OF TEST SUBSTANCE
- Washing: residual test substance was removed with warm water
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount applied: 0.5 g
- Constant volume or concentration used: yes, limit test
- For solids, paste formed: yes, 0.5 g test substance were moistened with 0.35 mL sesame oil
VEHICLE
- Amount applied: 0.35 mL - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing: animals were observed 15, 30, 60 min and 2, 4, and 6 h after dosing, twice daily from Day 2 to 6 and daily thereafter until the end of the observation period; individual body weights were determined weekly
- Necropsy of survivors performed: yes
- Examinations performed: clinical signs, body weight, assessment of macroscopic changes at necropsy - Statistics:
- Mean body weights and standard deviations were calculated.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- no indication of skin irritation up to the relevant limit dose level
- Mortality:
- No mortality occurred during the study period.
- Clinical signs:
- other: No clinical signs of toxicity were observed during the 15-day observation period in 5/5 male and 4/5 female animals. 1/5 females showed alopecia and an encrusted skin surface on its rump, which did not affect the treated skin area. These findings were con
- Gross pathology:
- Necropsy revealed no substance-related findings.
- Other findings:
- No local effects on the treated skin area were observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP: not classified
- Conclusions:
- Based on the results of the present study, no classification for acute dermal toxicity according to Regulation (EC) 1272/2008 is warranted.
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