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EC number: 264-980-3 | CAS number: 64628-44-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002-03-27 to 2002-04-23
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 2-chloro-N-[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]benzamide
- EC Number:
- 264-980-3
- EC Name:
- 2-chloro-N-[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]benzamide
- Cas Number:
- 64628-44-0
- Molecular formula:
- C15H10ClF3N2O3
- IUPAC Name:
- 3-(2-chlorobenzoyl)-1-[4-(trifluoromethoxy)phenyl]urea
- Test material form:
- solid: particulate/powder
1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Male and female (nulliparous and nonpregnant) Wistar Hanover (Crl: WI[Glx/BRL/HAN]GS BR) rats from Charles River Laboratories, Inc., (Raleigh, NC) were used in this study. These animals were approximately 11 weeks of age when treatment was administered.
Feed and Water. Feed (PMI Certified Rodent Diet 5002 in "meal" form, St. Louis, MO) and tap water (Kansas City Missouri municipal water, dispensed by automatic watering system) were provided continuously for ad libitum consumption during the acclimation period and throughout the study. Feed and water were periodically sampled and analyzed for a variety of potential impurities. The results of these analyses were unremarkable. Contaminant concentrations outlined in the Certification Profile for Purina Mills Certified Lab Chows (PMI Nutrition International, 1998) were used as a general standard by which to gauge acceptable levels of contaminants in the feed.
Examination and Acclimation. Upon receipt, animals were examined. No animals were sacrificed due to general appearance and/or abnormal behavior. Those animals considered acceptable were then placed into individual cages and acclimated to their ambient laboratory conditions (set for a temperature of 19-25ºC, relative humidity 30-70%, 12-hr light/dark cycles, 12 air changes /hour) for seven days prior to placement on the study. For the holding period, animal care personnel observed the animals at least once daily for moribundity and mortality.
Care and Housing. While on study, rats were individually housed in suspended stainless steel cages. The cages and cage racks were thoroughly cleaned and disinfected before arrival of the animals. Deotized Animal Cage Board was used in the bedding trays and changed at least two times weekly. The cages, feeders and racks were replaced at least once every two weeks with clean, disinfected equipment. The room was disinfected at least once every two weeks.
Randomization. Randomization by weight stratification utilized software from INSTEM Computer Systems (Stone, Staffordshire, UK). Following seven days of acclimation, animals were weighed. All animals placed on study were within 20% of the mean of all available animals.
These animals were randomly assigned to a control group, or to a single dose group (per sex) in order that, groups had equivalent body weights when treatment was initiated.
Administration / exposure
- Type of coverage:
- semiocclusive
- Details on dermal exposure:
- The dermal route of exposure was employed in general accordance with the test guidelines for an acute limit test dermal toxicity study, based on this being a possible route of human exposure.
The hair from the scapulae (shoulders) to the wing of the ileum (hipbone) and half-way down the flank on each side of the animal was removed using Oster electric clippers equipped with a number 40 blade. Animals were clipped approximately 24 hours before the first dose was administered and as necessary thereafter, depending on hair growth. Care was taken during clipping to avoid abrading the skin. The dose site was distinguished from the surrounding untreated skin by marking with a felt-tip marker. Animals were treated with the test material Triflumuron as received (neat), administered as a single dose for a duration of 24 hours. Dose amounts (mg/kg body weight) were based on individual body weight measurements determined on day 0. The appropriate quantity of dose was moistened with 25ul of deionized water and applied directly onto an area of the back of the animal, representing approximately 10% of it’s total surface areab. A two-ply gauze pad with plastic backing was applied over the treatment site and secured with hypoallergenic tape. The gauze was further secured with Vetrap© (Animal Care Products/3M, St. Paul, MN) bandage, which was also secured with tape. - Duration of exposure:
- 24 hours
- Doses:
- 5000 mg/kg bw/day
- No. of animals per sex per dose:
- 6
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- All animals were fitted with Elizabethan collars (EJAY International, Glendora, CA), which served to reduce animal access to the dose site and thereby reduce ingestion of the test substance, and returned to their cages.
After approximately 24 hours post-dosing (minimum), the bandages and gauze were removed and the dose site was wiped using paper towels dampened with tap water to remove as much of the residual test substance as feasible without damaging the skin. Animals were sacrificed 14 days after dosing. Both controls and treated rats were treated in an identical manner with the exception that the control group did not receive test substance.
Clinical Signs, Body Weights. Cage-side observations were conducted at least once daily for mortality or moribundity. No animals were sacrificed due to moribundity. Detailed physical examinations for clinical signs were carried out twice daily on three days (0, 1 and 2) and once daily for the remaining portion of the in-life phase of the study. These examinations were performed at approximately the same time each day. Body weights were determined on day 0, and on days 7 and 14.
Gross Pathology. Animals were sacrificed by CO2 asphyxiation and subjected to a gross necropsy examination. - Statistics:
- Descriptive statistics were generated by Datatox software (Stone, Staffordshire, UK).
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- no indication of skin irritation up to the relevant limit dose level
- Mortality:
- no mortality occurred.
- Clinical signs:
- other: other: Lacrimal and nasal staining, in the form of red discharge, in control and the 5000 mg/kg dose groups, were attributed to the animals wearing Elizabethan collars, which interfere with normal rodent preening, and were not considered to be compound-re
- Gross pathology:
- There were no gross observational findings at necropsy. No evidence of systemic toxicity was found.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal LD50 of triflumuron was found to be >5000 mg/kg bw under the conditions of this study.
- Executive summary:
Triflumuron technical formulated in deionized water was administered to 6 fasted male and female CD-1 rats by single gavage at 5000 mg/kg bw/day. Control animals were treated with deionized water only (10 mL/kg bw). Rats were observed for 14 days. The administration of triflumuron technical did not elicit any mortality or treatment-related findings in clinical signs, body weight and macroscopic pathology. The acute dermal LD50 of triflumuron technical was found to be >5000 mg/kg bw under the conditions of this study.
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