Registration Dossier
Registration Dossier
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EC number: 410-690-9 | CAS number: 103055-07-8 CGA 184699
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 Feb 2000 to 17 Feb 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: CIPAC method MT 157.3 (Water Solubility)
- GLP compliance:
- yes
- Medium:
- acetone
- Solubility:
- 460 g/L
- Temp.:
- 25 °C
- Medium:
- other: dichloromethane
- Solubility:
- 84 g/L
- Temp.:
- 25 °C
- Medium:
- ethyl acetate
- Solubility:
- 330 g/L
- Temp.:
- 25 °C
- Key result
- Medium:
- other: Hexane
- Solubility:
- 100 mg/L
- Temp.:
- 25 °C
- Medium:
- methanol
- Solubility:
- 52 g/L
- Temp.:
- 25 °C
- Medium:
- other: octanol
- Solubility:
- 8.2 g/L
- Temp.:
- 25 °C
- Medium:
- toluene
- Solubility:
- 66 g/L
- Temp.:
- 25 °C
- Test substance stable:
- yes
- Conclusions:
- The solubility in seven organic solvents was found to range from 0.1 g/L in hexane to 460 g/L in acetone.
- Executive summary:
The solubility of test substance was determined in seven organic solvents. As there is no general method available for the determination of the solubility in organic solvents, a procedure similar to that described in CIPAC method MT 157.3 (water solubility: flask method) was used in this study in compliance with GLP. The solubility was found to range from 0.1 g/L in hexane to 460 g/L in acetone.
Reference
Table 1. Results of solubility
Solvent |
[Amount of test substance] dispersed in [Amount of solvent] |
Equilibration time at 25 °C solubility |
Average solubility |
|
|
(g)/(mL) |
Day 1 (g/L) |
Day 2 (g/L) |
(g/L) |
Acetone |
28.86 g / 15.0 mL |
459.852 |
463.853 |
460 |
Dichloromethane |
9.31 g / 50.0 mL |
85.551 |
81.663 |
84 |
Ethyl Acetate |
13.93 g / 25.0 mL |
323.991 |
328.251 |
330 |
Hexane |
1.26 g / 100.0 mL |
0.102389 |
0.099361 |
0.1 |
Methanol |
5.98 g / 40.0 mL |
52.666 |
51.823 |
52 |
Octanol |
3.12 g / 50.0 mL |
8.077 |
8.338 |
8.2 |
Toluene |
11.60 g / 50.0 mL |
67.844 |
64.836 |
66 |
Description of key information
Solubility: The solubility was found to range from 0.1 g/L in hexane to 460 g/L in acetone, dichloromethane, ethyl acetate, methanol, octanol and toluene, similar to CIPAC MT 157.3 (water solubility), flask method, Kettner 2000
Key value for chemical safety assessment
- At the temperature of:
- 25 °C
- Solubility in organic solvents at 20°C:
- 100 mg/L
Additional information
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