Registration Dossier
Registration Dossier
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EC number: 604-604-0 | CAS number: 147770-06-7
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- flask method
Test material
- Reference substance name:
- 2-Ethoxy-4-{3-[(S)-3-methy-1-(2-piperidin-1-yl-phenyl)-butylamino]-2-oxo-propyl}-benzoic acid ethyl ester
- EC Number:
- 604-604-0
- Cas Number:
- 147770-06-7
- Molecular formula:
- C29 H40 N2 O4
- IUPAC Name:
- 2-Ethoxy-4-{3-[(S)-3-methy-1-(2-piperidin-1-yl-phenyl)-butylamino]-2-oxo-propyl}-benzoic acid ethyl ester
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- < 0.1 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 5 d
- Temp.:
- 20 °C
- Remarks on result:
- other: lower than quanitification limit
Applicant's summary and conclusion
- Conclusions:
- In conclusion, the water solubility of AGEE 623 Amidester was determined to be lower than the quantification limit (0.1 mg/L) at room temperature (about 20°C).
- Executive summary:
The determination of the Water Solubility of AGEE 623 Amidester was based on the EEC directive 92/69, Annex V, Part A, Methods for the determination of physico-chemical properties, A.6 “Water solubility”, EEC Piblication No. L383 (December 1992) and the OECD No. 105, “Water solubility” (July 1995) and EPA Product Properties Test Guideline OPPTS 830.7840 and 830.7860 (1996).
The water solubility of AGEE 623 Amidester was estimated to be < 1 g/L by visual judgement in the preliminary test.
The saturation concentration of AGEE 623 Amidester at room temperature was analytically estimated by a simplified flask method in an additional pre-test. After a pre-incubation of 5 days at 30°C in a shaking water bath, the concentration of the saturated solutions prepared were determined to be < 0.1 mg/l (quantification limit). Therefore no further solubility tests were performed.
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