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Diss Factsheets
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EC number: 201-579-4 | CAS number: 85-00-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- photometric method
- Key result
- Type:
- log Pow
- Partition coefficient:
- -4.6
- Temp.:
- 20 °C
- Remarks on result:
- other: no pH has been reported
- Details on results:
- The octanol-water partition coefficient, Log Pow, is -4.6 at approximately 20 °C. Since the test substance is strongly ionic the Log Pow is expected to be negative; the equilibrium being heavily in favour of the aqueous phase. This was borne out in the results, the levels detected in the octanol phase were unreliable and in most cases the peak attributed to the substance dicationic species had a peak height in the region of the lowest standard (0.02 µg/cm3). This accounts for the variability in the individual Log Pow results. However, the results confirm that the Log Pow is substantially less than 0 and not biologically significant in terms of bioaccumulation. Results are detailed in Table 1 in 'Any other information on results incl. tables'.
- Conclusions:
- The mean log Pow was determined to be -4.6 at 20 °C.
- Executive summary:
The 1-octanol / water partition coefficient (Pow) of the test substance has been determined in accordance with the OECD TG 107 using the shake-flask method, and in compliance with GLP. The mean log Pow was -4.6 at 20 °C.
Reference
Table 1 Partition Coefficient Results
Ratio, Replicate |
CocT (%w/v) |
CAa (%w/v) |
Pow |
LogPow |
1:1, 1 |
3.47 E-06 |
0.370 |
9.38 E-06 |
-5.03 |
1: 1, 2 |
6.55 E-06 |
0.365 |
1.79E-05 |
-4.75 |
4:1, 1 |
2.94 E-05 |
0.377 |
7.80 E-05 |
-4.11 |
4:1, 2 |
1.74E-05 |
0.378 |
4.60 E-05 |
-4.34 |
3:2, 1 |
7.51 E-06 |
0.371 |
2.02 E-05 |
-4.69 |
3:2, 2 |
8.28 E-06 |
0.369 |
2.24 E-05 |
-4.65 |
|
Mean [2 Sig. Figs.] |
-4.6 (Sr 7.1 %) |
Description of key information
Log Kow = -4.6 at 20 °C, OECD TG 107, flask method, Husband 2001.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -4.6
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.