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EC number: 860-352-3 | CAS number: 1610350-91-8
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2020-02-24 to 2020-04-27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7950 (Vapor Pressure)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: vapour pressure balance
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 0.001 Pa
- Temp.:
- 50 °C
- Vapour pressure:
- 0.006 Pa
- Conclusions:
- The vapour pressure of the test item was calculated to be 3.1E-4 Pa at 20, 5.3E-4 Pa at 25 and 5.8E-3 Pa at 50 °C, respectively.
- Executive summary:
A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item using the effusion method: vapour pressure balance. The thermal stability of the test item was determined with the DSC method. Starting at a temperature of 160 °C an exothermic effect with an energy release of -50 J/g can be observed. An endothermic effect observed starting at a temperature of 250 °C. Thus, the vapour pressure of the test item was determined at temperatures between 37 and 68 °C. Using the Antoine equation, the constants A and B were determined and the vapour pressure of the test item at 20, 25 and 50 °C was interpolated and extrapolated from the experimental vapour pressure. The vapour pressure was calculated to be 3.1E-4 Pa at 20, 5.3E-4 Pa at 25 and 5.8E-3 Pa at 50 °C, respectively.
Reference
Thermal Stability
Starting at a temperature of 160 °C an exothermic effect with an energy release of -50 J/g can be observed. An endothermic effect observed starting at a temperature of 250 °C.
Table 1: Results of the DSC-measurement
No. |
Sample weight / mg |
Start / °C |
Energy / J/g |
PN19280 |
7.00 |
160 |
-50 (exothermic) |
Effusion method: Vapour pressure balance
The vapour pressure was measured in the temperature range of 37 to 68 °C.
Table2: Results of the Effusion method
No. |
Temperature / °C |
Vapour pressure / Pa |
1 |
37 |
1.86E-3 |
2 |
42 |
2.76E-3 |
3 |
47 |
4.22E-3 |
4 |
52 |
6.79E-3 |
5 |
58 |
1.18E-2 |
6 |
63 |
1.75E-2 |
7 |
68 |
2.74E-2 |
From the measured data points of the vapour pressure curve the constants A and B of the Antoine equation can be derived by regression of the data points to be:
A = 10.2276
B = -4027.25
C = 273.15.
The vapour pressure of the test item was calculated by interpolation and extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50°C.
Table3: Calculated vapour pressure values for 20, 25 and 50 °C
Temperature / °C |
Vapour pressure / Pa |
20 |
3.1E-4 |
25 |
5.3E-4 |
50 |
5.8E-3 |
Description of key information
The vapour pressure of the test item was calculated to be 3.1E-4 Pa at 20, 5.3E-4 Pa at 25 and 5.8E-3 Pa at 50 °C, respectively (reference 4.6-1).
Key value for chemical safety assessment
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 20 °C
Additional information
A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item using the effusion method: vapour pressure balance. The thermal stability of the test item was determined with the DSC method.Starting at a temperature of 160 °C an exothermic effect with an energy release of -50 J/g can be observed. An endothermic effect observed starting at a temperature of 250 °C.Thus, the vapour pressure of the test item was determined at temperatures between 37 and 68 °C. Using the Antoine equation, the constants A and B were determined and the vapour pressure of the test item at 20, 25 and 50 °C was interpolated and extrapolated from the experimental vapour pressure. The vapour pressure was calculated to be 3.1E-4 Pa at 20, 5.3E-4 Pa at 25 and 5.8E-3 Pa at 50 °C, respectively.
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