10-oxo-10H-dibenzo[b,e]thiopyran-4-carboxylic acid

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2020

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

GLP compliance:

yes (incl. QA statement)

Test type:

fixed dose procedure

Test material

Test material information

Constituent 1

Reference substance name:

9-oxo-9H-thioxanthene-4-carboxylic acid

EC Number:

849-175-2

Cas Number:

51762-56-2

Molecular formula:

C14H8O3S

IUPAC Name:

9-oxo-9H-thioxanthene-4-carboxylic acid

Test animals

Species:

rat

Strain:

Wistar

Sex:

female

Administration / exposure

Route of administration:

oral: drinking water

Vehicle:

olive oil

Details on oral exposure:

14-days observation period.

Doses:

The starting dose was selected from the fixed dose levels of 5, 50, 300, and 2000 mg/kg body weight.

No. of animals per sex per dose:

6 females

Results and discussion

Effect levels

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Clinical signs:

other: No signs of intoxication, change of health, nor any other adverse reactions during 24 hours and 14-days observation period at limit dose of 2000 mg/kg body weight was observed. Animals No 1-3 exhibit slight piloerection after 2 hours from administration a

Gross pathology:

All animals were necropsied. No visible pathological findings were observed in animals dosed with 2000 mg/kg body weight.