Sodium methanethiolate

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Data source

Reference

Reference 1

Reference Type:

review article or handbook

Title:

SIDS Dossier

Author:

OECD

Year:

2008

Bibliographic source:

OECD SIDS Dossier - sodium methanethiolate

Reference 2

Reference Type:

other: Unpublished report

Title:

Unnamed

Year:

1989

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Version / remarks:

adopted 1981

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Sodium methanethiolate

EC Number:

225-969-9

EC Name:

Sodium methanethiolate

Cas Number:

5188-07-8

Molecular formula:

CH4S.Na

IUPAC Name:

sodium methylsulfanide

Test material form:

liquid

Specific details on test material used for the study:

- Test article name : Sodium methylmercaptide
- CAS No: 5188-07-8
- Origin: Atochem, Pilote UDL-AE no. 83562
- Batch: 897016
- Composition: Sodium methylmercaptide: 19.9% solution in water, Na2S: 0.30%, Free NaOH: 1.1%, releasable NaOH: 12.75%

Test animals

Species:

rabbit

Strain:

New Zealand White

Test system

Type of coverage:

semiocclusive

Preparation of test site:

clipped

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Amount / concentration applied:

0.5 mL

Duration of treatment / exposure:

4 hours

Observation period:

1 and 24 hours

Number of animals:

1 male

Details on study design:

A single dose of 0.5 mL of the test substance was prepared in its original form in a gauze patch then applied to 6 cm² clipped area to 1 male New Zealand White rabbit. The test substance was held in contact with the skin for 4 hours by means of a semi-occlusive dressing. Residual test substance was removed by means of a dry dressing. The cutaneous reactions were observed 1 hour and 24 hours after removal of the dressing.

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

other: necrosis

Basis:

animal #1

Time point:

other: 1 hour

Reversibility:

not reversible

Results 2

Irritation parameter:

other: necrosis

Basis:

animal #1

Time point:

24 h

Reversibility:

not reversible

Remarks on result:

other: The animal was sacrificed after scoring at 24 hours.

Irritant / corrosive response data:

One hour and 24 hours after the removal of the dressing, necrosis signs were observed at application site of the test substance. The animal was sacrificed after scoring at 24 hours.

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Conclusions:

In this study and under the given conditions the test item showed corrosive effects.

Executive summary:

In a primary dermal irritation study (OECD TG 404) one male New Zealand White rabbit was dermally exposed to 0.5 mL of the test item Sodium methanethiolate (19.9% solution in water) for 4 hours under semi-occlusive conditions. Irritation was scored at 1 and 24 hours. Exposure to the test article for a 4-hour exposure period produced necrosis signs by the 1-hour and 24-hour observation periods. The animal was sacrificed after scoring at 24 hours.

Based on the results, the test substance is considered to be corrosive to the skin of the rabbit after a 4-hour exposure period.