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EC number: 435-080-1 | CAS number: 1070-64-0 6,8-DICHLORETHYLCAPRYLAT; ETHYL-6,8 DICHLORO OCTANOATE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Effects of the test substance were noted in the high and the mid dosed amimals of both sexes at observations in life, and clinical chemistry, organ weight determination and at histopathological examination.
Two major effects of the test substance were thereby elucidated:
Firstly, the test substance caused salivation for a short time after administration. This could be due to a vagotonic effect or to an extremely poor palatability, as minimal amounts to the test may be deposited in the oral cavity even at a careful gavage.
Secondly, the test substance is hepatotoxic. Findings at clinical chemistray, organ weight determiantion and histopathology together indicate the presence of a mild hepatocellular degeneration.
Some other significant differences or abnormal findigs are considered to be incidental significances (e. g. in the feed consumption, heart weight changes etc.) or secondary changes (adrenal weight increase due to chronic stress).
The changes noted did not become life threatening.
The hepatic changes partly persisted until the end of the recovery period, but were clearly reduced in severity.
There was no marked sex differende in the dose response.
Toxic effects were present in the mid and the high dosed group of both exes, none were observed in the low dosed group.
Based on the results of the study, the NOAEL is 60 mg 6,8 Dichloroethylcaprylate per kg body weight and day in rats of both sexes
Key value for chemical safety assessment
- Toxic effect type:
- dose-dependent
Repeated dose toxicity: via oral route - systemic effects
Link to relevant study records
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000-01-14 to 2000-05-10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity Study in Rodents)
- GLP compliance:
- yes (incl. QA statement)
- Limit test:
- no
- Specific details on test material used for the study:
- Batch: Ds 1099
- Species:
- rat
- Strain:
- Fischer 344
- Remarks:
- "CDF (F344)/CRLBR, SPF." as cited in Report
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Room temperature Average 20.7°; humidity average 49.2%
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 0.5% Solution in Water
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 28 days
- Frequency of treatment:
- once a day
- Dose / conc.:
- 0 mg/kg bw/day (nominal)
- Dose / conc.:
- 60 mg/kg bw/day (nominal)
- Dose / conc.:
- 190 mg/kg bw/day (nominal)
- Dose / conc.:
- 600 mg/kg bw/day (nominal)
- Dose / conc.:
- 600 mg/kg bw/day (nominal)
- Remarks:
- recovery group
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- yes, concurrent vehicle
- Positive control:
- no
- Observations and examinations performed and frequency:
- Body weight; chromodqakryorrhoea, diarrhoea, salivation, behaviour, feed consumption
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- effects observed, non-treatment-related
- Description (incidence and severity):
- Feed consumption of high dose recovery males and female was significantly hgher in teh last week of the dosing period (Day 21 through 28) compared to the controls this significance is not given toxicological importance.
- Haematological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- eosinophil granulocytes females higher in Low dose
cholesterol males lower in mid dose and high dose
cholesterol females lower in mid dose and high dose
alkaline phosphatase females higher in mid dose
ALT females higher in mid dose and high dose
AST females higher in mid dose and high dose
BUN females higher in mid dose and high dose
Na+ females lower in high dose - Behaviour (functional findings):
- no effects observed
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Description (incidence and severity):
- liver weight males higher in mid dose and hgh dose
liver weight females higher in mid dose and hgh dose
adrenals weight males higher in high dose after recovery
heart weight males lower in mid dose - Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 60 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- organ weights and organ / body weight ratios
- Critical effects observed:
- not specified
- Conclusions:
- Based on the results of the study, the NOAEL is 60 mg 6,8 Dichloroethylcaprylate per kg body weight and day in rats of both sexes
- Executive summary:
Effects of the test substance were noted in the high and the mid dosed amimals of both sexes at observations in life, and clinical chemistry, organ weight determination and at histopathological examination.
Two major effects of the test substance were thereby elucidated:
Firstly, the test substance caused salivation for a short time after administration. This could be due to a vagotonic effect or to an extremely poor palatability, as minimal amounts to the test may be deposited in the oral cavity even at a careful gavage.
Secondly, the test substance is hepatotoxic. Findings at clinical chemistray, organ weight determiantion and histopathology together indicate the presence of a mild hepatocellular degeneration.
Some other significant differences or abnormal findigs are considered to be incidental significances (e. g. in the feed consumption, heart weight changes etc.) or secondary changes (adrenal weight increase due to chronic stress).
The changes noted did not become life threatening.
The hepatic changes partly persisted until the end of the recovery period, but were clearly reduced in severity.
There was no marked sex differende in the dose response.
Toxic effects were present in the mid and the high dosed group of both exes, none were observed in the low dosed group.
Based on the results of the study, the NOAEL is 60 mg 6,8 Dichloroethylcaprylate per kg body weight and day in rats of both sexes
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 60 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- one short term repeated dose toxicity study has been performed according to guideline.
- Organ:
- liver
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on the study result a classification as STOT RE cat 2 / H373 is necessary
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