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EC number: 806-451-7 | CAS number: 42532-60-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 21 to July 10, 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch number of test material: 3M N.B # us278898.001-096
- Expiration date of the lot/batch: 10/30/2021
- Purity: 97.7%
- Physical state: White solid
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature
- Stability under storage conditions: Stable - Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Range finding test: 1.2, 12, 120 mg/L. Limit test: 120 mg/L
- 20 mL analytical samples were taken from each vessel at the beginning and end of the test, and before and after each renewal.
- Sample storage conditions before analysis: Samples were stored and refrigerated at 2-8° C if not analyzed within 24 hours - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION:
- Method: The test substance was dissolved in test medium to prepare a stock solution with a nominal concentration of 1000 mg/L. The test solutions were then prepared daily via dilution of the stock solution with test water.
- Controls: Blank control of test water. - Test organisms (species):
- other: Gobiocypris rarus
- Details on test organisms:
- TEST ORGANISM
- Common name: Chinese Rare Minnow
- Source: Bioassay and Safety Assessment Lab, Shanghai Academy of Public Measurement
- Length at study initiation: 1.7 ± 0.1cm (Mean ± SD) for fish from the same batch (n=10)
- Weight at study initiation: 0.10 ± 0.01g (Mean ± SD) for fish from the same batch (n=10)
ACCLIMATION
- Acclimation period: More than 9 days using test conditions.
- Type and amount of food during acclimation: Fish were fed with brine shrimp flakes (OSI, USA) daily until 24 hours before test.
- Health during acclimation (any mortality observed): No visible signs of disease, or malformations. Fish appeared stress free and were not treated for diseases nor parasites during the acclimation period. Less than 5% mortality in the population was observed before the test.
-Acclimation conditiions: Water: standatd dilution water, Temperature: 21-25 °C, pH: 6.0-8.5, Dissolved Oxygen: >80% air saturation value (ASV), Light: 12-16 hours per day. - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 145 mg CaCO3/L
- Test temperature:
- 21.3 - 21.6 °C
- pH:
- 6.74 - 7.68
- Dissolved oxygen:
- 71.2 - 93.8 % ASV
- Nominal and measured concentrations:
- Nominal: 120 mg/L.
Measured: A time-weighted average of 127 mg/L was calculated for 120 mg/L concentration. - Details on test conditions:
- TEST SYSTEM
- Test vessel: Five liter glass vessels with seals.
- Type: closed
- Material, size, headspace, fill volume: No headspace
- Aeration: Yes
- Renewal rate of test solution: Every 24 hours
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 0.2 g fish/L
TEST MEDIUM / WATER PARAMETERS
- Total organic carbon: 112.7 ug/L
- Salts were dissolved in deionized water (conductivity:≤10µs/cm) to form stock solutions and standard dilution water:
Stock a: Component CaCl2.2H2O, concentration 11.76 g/L
Stock b: Component MgSO4.7H2O, concentration 4.93 g/L
Stock c: Component KCl, concentration 0.23 g/L
Stock d: NaHCO3, concentration 2.59 g/L
Standard dilution water: 25mL of each solution (a-d) were mixed to the total volume of 1 liter with deionized water, which was then aereated over 24 hours.
OTHER TEST CONDITIONS
- Adjustment of pH: None
- Photoperiod: 12 hours dark: 12 hours light
- Light intensity: 810 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): Mortality and other effects (including visible physical and behavioral abnormalities) at 2, 5, 24, 28, 48, 52, 72, 76 and 96 hours.
TEST CONCENTRATIONS
- Range finding study : Yes
- Test concentrations: 1.2, 12, 120 mg/L
- Results used to determine the conditions for the definitive study: Yes, a limit test was run. - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichlorate
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 127 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other:
- Remarks:
- No effects observed on exposed fish.
- Details on results:
- Behavioural abnormalities: No
- Mortality of control: No
- Other adverse effects control: No
- Abnormal responses: No
- Effect concentrations exceeding solubility of substance in test medium: No - Results with reference substance (positive control):
- 96 hour LC50 = 182 mg/L (95% CI: 144-288 mg/L) for potassium dichromate on fish from the same lot
- Validity criteria fulfilled:
- yes
- Remarks:
- <10% mortality in controls (0%), DO >60% ASV (71.2 - 93.8 %)
- Conclusions:
- 96 hour LC50 >127 mg/L (OECD 203) in Gobiocypris rarus.
- Executive summary:
The 96 hour LC50 of Heptafluoropropylamide to Gobiocypris rarus was determined in a limit test according to OECD 203 guidelines. A nominal concentration of 120 mg/L and a blank control were run using 10 animals per tank. An LC50 >127 mg/L (time weighted average concentration) was determined. No mortality or adverse effects were observed at this concentration.
The study was well-documented, followed an international standard method and was GLP compliant.The study is considered reliable without restrictions.The results from this study are considered suitable for Risk Assessment, Classification and Labeling, and PBT Analysis.
Reference
Description of key information
96 hour LC50 >127 mg/L (OECD 203) in Gobiocypris rarus.
Key value for chemical safety assessment
Additional information
The 96 hour LC50 of Heptafluoropropylamide to Gobiocypris rarus was determined in a limit test according to OECD 203 guidelines. A nominal concentration of 120 mg/L and a blank control were run using 10 animals per tank. An LC50 >127 mg/L (time weighted average concentration) was determined. No mortality or adverse effects were observed at this concentration.
The study was well-documented, followed an international standard method and was GLP compliant.The study is considered reliable without restrictions.The results from this study are considered suitable for Risk Assessment, Classification and Labeling, and PBT Analysis.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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