Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 852-824-2 | CAS number: 1404220-73-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Report in compliance with current (1981) GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
- Remarks:
- The report in compliance with current (1981) GLPs.
Test material
- Reference substance name:
- Diisodecyl phenyl phosphite
- EC Number:
- 247-098-3
- EC Name:
- Diisodecyl phenyl phosphite
- Cas Number:
- 25550-98-5
- Molecular formula:
- C26H47O3P
- IUPAC Name:
- Phosphorous acid, diisodecyl phenyl ester
- Reference substance name:
- Phenyldiisodecyl Phosphite
- IUPAC Name:
- Phenyldiisodecyl Phosphite
- Details on test material:
- - Name of test material (as cited in study report): Phenyldiisodecyl Phosphite
- Substance type:
- Physical state: Liquid
- Composition of test material, percentage of components: 10% w/v suspension in Mineral Spirits
- Lot/batch No.: #PDDP-002-03240A
Constituent 1
Constituent 2
Test animals
- Species:
- guinea pig
- Strain:
- other: Albino
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: between 300 and 400 grams
- Sex: male
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other: suspension in Mineral Spirits
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5mL
- Concentration (if solution): 10% w/v
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.5mL
- Concentration (if solution): 90% - Duration of treatment / exposure:
- After 24 hour contact period patch removed; 1 day rest; second fresh patch applied to same skin site. Sequence repeated for total of 10 applications. After 10 applications animals rested for 2 weeks. At termination of rest period, challenge application was put on skin sites differing from the original test sites for 24 hours.
- Observation period:
- 24 hours after each induction stage application and 24 and 48 hours after the challenge (re-test) application, the sites were examined for irritation.
- Number of animals:
- 10
- Details on study design:
- TEST SITE
- Area of exposure: trunk
- % coverage:
- Type of wrap if used: impervious material
REMOVAL OF TEST SUBSTANCE
- Washing (if done): none
- Time after start of exposure: 24 hours
SCORING SYSTEM: Draize method
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 hrs
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48 hrs
- Score:
- 0.6
- Max. score:
- 1
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- All test subjects displayed slight erythema after each 24 hour exposure period (both repeat exposures and 24 hour challenge exposures). Six out of ten subjects showed slight erythema after the 48 hour challenge exposure. No subjects displayed signs of edema after any exposure.
Any other information on results incl. tables
Guinea Pig Contact Dermal Irritation/Sensitization Study
MALES
Reading After Application Number | Challenge | |||||||||||||
Guinea Pig No. | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 24 Hours | 48 Hours | ||
1 | Erythema | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
Edema | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||
2 | Erythema | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | |
Edema | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||
3 | Erythema | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
Edema | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||
4 | Erythema | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
Edema | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||
5 | Erythema | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | |
Edema | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||
6 | Erythema | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | |
Edema | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||
7 | Erythema | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
Edema | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||
8 | Erythema | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
Edema | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||
9 | Erythema | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | |
Edema | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||
10 | Erythema | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
Edema | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The material appears to be a mild primary skin irritant when tested as a 10% w/v suspension in mineral spirits. It does not appear to be a fatiguing agent or a sensitizing agent in the albino guinea pig.
- Executive summary:
A group of male albino guinea pigs were used to assess the contact dermal irritation/sensitization potential of phenyldiisodecyl phosphite (CAS # 25550 -98 -5) prepared as a 10% w/v suspension in mineral spirits. A 0.5mL portion of the material was applied to intact skin test sites and wrapped with gauze and impervious material. The wrap was left on for 24 hours, then taken off for the animals to rest for 24 hours. The material was then applied to the same area and re-wrapped; this sequence was repeated 10 times followed by a 2 week rest period. At the termination of the rest period, a challenge application was put on skin sites different than the original test sites. The challege application remained for 24 hours.
Twenty-four hours after each induction stage application and 24 and 48 hours after teh challenge application, the sites were examined for irritation using the Draize method of scoring to grade reactions.
When tested as a 10% w/v suspension in mineral spirits, the material appears to be a mild primary skin irritant . It does not appear to be a fatiguing agent or a sensitizing agent in the albino guinea pig.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.