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Reaction mass of lithium sodium hydrogen 4-amino-6-({5-[(5-chloro-2,6-difluoropyrimidin-4-yl)amino]-2-sulfonatophenyl}diazenyl)-5-hydroxy-3-[(4-{[2-(sulfonatooxy)ethyl]sulfonyl}phenyl)diazenyl]naphthalene-2,7-disulfonate and lithium sodium hydrogen 4-amino-6-({5-[(5-chloro-2,6-difluoropyrimidin-4-yl)amino]-2-sulfonatophenyl}diazenyl)-5-hydroxy-3-{[4-(vinylsulfonyl)phenyl]diazenyl}naphthalene-2,7-disulfonate
EC number: 941-533-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From July 08, 1986 to September 07, 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- The study was conducted according to an internal standard method, with quality assurance but not under GLP. No analytical determination of test concentrations.
- Principles of method if other than guideline:
- 6-24 d old Daphnia magna were exposed to the test substance in a static system for a duration of 24 h. The exposure doses were equivalent to 0, 300, 400 and 500 mg/L (nominal). The positive control potassium dichromate was tested in parallel at 0.75, 1.0, 1.25, 1.50, 1.75, 2.0, 3.0 and 5.0 mg/L. There were 5 Daphnia per 10 mL vessel and 4 vessels per test concentration.
The number of immobile Daphnia was recorded at 24 h. Oxygen concentration, pH and temperature were measured in each of the test vessels. - GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 24 h
- Test temperature:
- 19.5 - 21°C
- pH:
- 7.9-8.2
- Dissolved oxygen:
- 8.5-8.7 mg/L
- Nominal and measured concentrations:
- - Nominal concentration: 0, 300, 400 and 500 mg/L
- Details on test conditions:
- - Test vessel: Cylindrical test vessels (diameter 2.6 cm, height 6.2 cm)
- Volume: 10 mL test medium - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- >= 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- 300 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- The 24 h EC0, EC50 and EC 100 for the reference substance were 0.75, 1.92 and 5.0 mg/L, respectively.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the test conditions, the nominal 24 h EC50 of the test substance was determined to be >500 mg/L.
- Executive summary:
A test was conducted to determine the acute toxicity of the test substance to Daphnia magna according to an internal standard operating procedure. In this test, 4 replicates of 5 daphnids were exposed to the substance at nominal concentrations of 0, 300, 400 and 500 mg/L under static conditions for 24 h. Immobility was recorded at 24 h, along with measurement of oxygen concentration, pH and temperature. The positive control potassium dichromate was tested in parallel at 0.75, 1.0, 1.25, 1.50, 1.75, 2.0, 3.0 and 5.0 mg/L. 1 daphnid each died at 400 and 500 mg/L. Therefore, under the study conditions, the nominal 24 h EC50 of the test substance was determined to be >500 mg/L (Caspers, 1986).
Reference
Description of key information
The nominal 24 h EC50 of the test substance was determined to be >500 mg/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 500 mg/L
Additional information
A test was conducted to determine the acute toxicity of the test substance to Daphnia magna according to an internal standard operating procedure. In this test, 4 replicates of 5 daphnids were exposed to the test substance at nominal concentrations of 0, 300, 400 and 500 mg/L under static conditions for 24 h. Immobility was recorded at 24 h, along with measurement of oxygen concentration, pH and temperature. The positive control potassium dichromate was tested in parallel at 0.75, 1.0, 1.25, 1.50, 1.75, 2.0, 3.0 and 5.0 mg/L. 1 daphnid each died at 400 and 500 mg/L. Therefore, under the study conditions, the nominal 24 h EC50 of the test substance was determined to be >500 mg/L (Caspers, 1986).
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