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EC number: 951-275-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental starting date: 13 December 2017 Experimental completion date: 07 March 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- (2008)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- (2001)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Specific details on test material used for the study:
- Identification: FRET 14-0383
Appearance/physical state: colorless liquid
Batch: RDGM435-97
Purity: 95.1%
Expiry date: 01 January 2019
Storage conditions: approximately 4 °C, in the dark - Radiolabelling:
- no
- Test temperature:
- 30°C
- Details on study design: HPLC method:
- The test system utilized a high performance liquid chromatograph and a cyanopropyl reverse phase HPLC column, containing lipophilic and polar moieties was used.
Performance of the Test
Preparation of sample solution
Test item (0.1132 g) was diluted to 100 mL with methanol. This solution was then diluted by a factor of 10 with methanol to give a concentration of 113 mg/L, prior to analysis.
Preparation of dead time solution
The dead time was determined by measuring the retention time of formamide (purity* 99.6%, 675 mg/L solution in methanol).
Determination of retention time
The sample, dead time and reference standard solutions were injected in duplicate using the following HPLC parameters:
HPLC System : Agilent Technologies 1100 Series, incorporating autosampler and workstation
Detector type : ultraviolet (UV)
Column : Zorbax Eclipse XDB-CN 5 μm (150 x 4.6 mm id)
Column temperature : 30 ºC
Mobile phase : methanol: water (55:45 v/v)
pH of mobile phase : 6.0
Flow-rate : 1.0 mL/min
Injection volume : 10 μL
UV detector wavelength : 210 nm
Calculation
The capacity factors (k') for the reference standards were calculated using:
k' = (tr-t0)/t0
where:
k'= capacity factor
tr= retention time (min)
t0= dead time (min)
A correlation of log k' versus log Koc of the calibration standards was plotted using linear regression. The adsorption coefficient was calculated using the following equation:
Log10 Koc = (Log10 k' - A)/B
where:
Koc= adsorption coefficient
k'= capacity factor
A= intercept of the calibration curve
B= slope of the calibration curve - Key result
- Type:
- log Koc
- Value:
- 3.16 dimensionless
- pH:
- 6
- Temp.:
- 30 °C
- Details on results (HPLC method):
- The method guidelines state that the measurement of adsorption coefficient should be carried out on substances in their ionized and unionized forms, within the environmentally relevant pH range, where applicable. However, in the absence of any dissociating functional groups, this was not necessary for this test item and therefore only a single determination was performed, at an approximately neutral pH, on the test item in an unionized form.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient (Koc) of the test item has been determined to be 1450, log10Koc 3.16.
- Executive summary:
The HPLC screening method was applied for the determination of the adsorption coefficient (Koc) of FRET 14 -0383.The mobile phase was 55/45 (v/v) methanol/water. The column temperature was 30°C. The log Koc value of the test substance was 3.16 (Koc = 1450).The study was performed in accordance with EC C.19 and OECD 121 and according to the principles of GLP.
Reference
Calibration
The retention times of the dead time and the retention times, capacity factors (k') and log10Koc values for the reference standards are shown in the two following tables:
Dead time |
Retention time (mins) |
Mean retention time (mins) |
|
Injection 1 |
Injection 2 |
||
Formamide |
1.657 |
1.659 |
1.658 |
Standard |
Retention time (mins) |
Capacity factor (k') |
Log10k' |
Log10Koc |
||
Injection 1 |
Injection 2 |
Mean |
||||
Acetanilide |
2.147 |
2.147 |
2.147 |
0.295 |
-0.530 |
1.25 |
Phenol |
2.203 |
2.203 |
2.203 |
0.328 |
-0.484 |
1.32 |
Atrazine |
2.557 |
2.559 |
2.558 |
0.543 |
-0.265 |
1.81 |
Triadimenol |
3.421 |
3.418 |
3.419 |
1.062 |
2.62 x 10-2 |
2.40 |
Linuron |
4.059 |
4.059 |
4.059 |
1.448 |
0.161 |
2.59 |
Naphthalene |
3.765 |
3.763 |
3.764 |
1.270 |
0.104 |
2.75 |
Endosulfan-diol |
5.114 |
5.109 |
5.112 |
2.083 |
0.319 |
3.02 |
Fenthion |
6.689 |
6.686 |
6.687 |
3.033 |
0.482 |
3.31 |
a-Endosulfan |
8.144 |
8.144 |
8.144 |
3.911 |
0.592 |
4.09 |
Diclofop-methyl |
7.858 |
7.853 |
7.855 |
3.737 |
0.573 |
4.20 |
Phenanthrene |
6.579 |
6.577 |
6.578 |
2.967 |
0.472 |
4.09 |
DDT |
17.637 |
17.632 |
17.635 |
9.635 |
0.984 |
5.63 |
Adsorption Coefficient
The retention times, capacity factor and log10 Koc value determined for the sample are shown in the following table:
Injection |
Retention time (mins) |
Capacity factor (k') |
Log10k' |
Log10Koc |
Mean |
Adsorption coefficient |
1 |
4.573 |
1.758 |
0.245 |
3.16 |
3.16 |
1.45 x 103 |
2 |
4.571 |
1.756 |
0.245 |
3.16 |
Description of key information
The HPLC screening method was applied for the determination of the adsorption coefficient (Koc) of FRET 14 -0383.The mobile phase was 55/45 (v/v) methanol/water. The column temperature was 30°C. The log Koc value of the test substance was 3.16 (Koc = 1450).The study was performed in accordance with EC C.19 and OECD 121 and according to the principles of GLP.
Key value for chemical safety assessment
- Koc at 20 °C:
- 3.16
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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