1-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)ethanone

Endpoint summary

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information

The molecule was predicted to be NON mutagenic.

Link to relevant study records

Reference

Endpoint:

in vitro gene mutation study in bacteria

Type of information:

(Q)SAR

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Justification for type of information:

Documentation about the justification is provided in attachment (See Supporting information). The reliability assessment of the prediction is presented in the attached document as well (QPRF).

Qualifier:

equivalent or similar to guideline

Guideline:

other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.

Type of assay:

bacterial reverse mutation assay

Specific details on test material used for the study:

CC(=O)N1C2=CC=CC=C2CCC3=CC=CC=C31

Genotoxicity:

negative

Remarks on result:

no mutagenic potential (based on QSAR/QSPR prediction)

The prediction was deemed to be reliable on the basis of the parameters listed above. The molecule falls into the applicability domain of the model.

Conclusions:

The molecule was predicted to be NON mutagenic.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (negative)

Justification for classification or non-classification

Although the molecule is reliably predicted to be non mutagenic, data available are deemed to be inconclusive for the classification in accordance with CLP regulation.