1,3-diethenyl-1,1,3,3- tetramethyldisiloxane and its platinum(0) complexes

Biodegradation in water: screening tests

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

biodegradation in water: screening test, other

Remarks:

(Q)SAR model

Type of information:

(Q)SAR

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Justification for type of information:

1. SOFTWARE: Biowin – Ready biodegradation model

2. MODEL: Biowin v4.10 [EPISuite v4.11]

3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL: SMILES: C=C[Si](O[Si](C=C)(C)C)(C)C

4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
QMRF and QPRF attached in IUCLID.

Principles of method if other than guideline:

The Biodegradation Probability Program (Biowin) estimates the probability for the rapid aerobic biodegradation of an organic chemical in the presence of mixed populations of environmental microorganisms. Estimates are based upon fragment constants that were developed using multiple linear and non-linear regression analyses.

GLP compliance:

no

Specific details on test material used for the study:

Estimation conducted based on the following data:
CHEMICAL NAME: Disiloxane, 1,3-diethenyl-1,1,3,3-tetramethyl-
MOLECULAR FORMULA: C8 H18 O1 Si2
MOLECULAR WEUGHT : 186.40

Oxygen conditions:

other: Not applicable

Inoculum or test system:

other: Not applicable

Details on inoculum:

Not applicable

Preliminary study:

Not applicable

Details on results:

Ready Biodegradability Prediction: NO based on the following predictions
Biowin1 (Linear Model Prediction): 0.6588
Biowin2 (Non-Linear Model Prediction): 0.5895
Biowin3 (Ultimate Biodegradation Timeframe): 2.7872
Biowin4 (Primary Biodegradation Timeframe): 3.5788
Biowin5 (MITI Linear Model Prediction): 0.1964
Biowin6 (MITI Non-Linear Model Prediction): 0.0687
Biowin7 (Anaerobic Model Prediction): 0.0767

Predictions from Biowin models:

  Biowin1 (Linear Model Prediction):  Biodegrades Fast

  Biowin2 (Non-Linear Model Prediction):  Biodegrades Fast

  Biowin3 (Ultimate Biodegradation Timeframe):  Weeks

  Biowin4 (Primary  Biodegradation Timeframe):  Days-Weeks

  Biowin5 (MITI Linear Model Prediction):  Not Readily Degradable

  Biowin6 (MITI Non-Linear Model Prediction):  Not Readily Degradable

  Biowin7 (Anaerobic Model Prediction):  Does Not Biodegrade Fast

Conclusions:

The substance is a solution of an inorganic salt and the biodegradability is considered to be relevant only to the organic component. The organic component, 1,3-divinyl-1,1,3,3-tetramethyldisiloxane, is considered not readily biodegradable.

Executive summary:

The substance is a solution of an inorganic salt and the biodegradability is considered to be relevant only to the organic component. The biodegradability of the organic component, 1,3 -divinyl-1,1,3,3 -tetramethyldisiloxane, is taken from Biowin, a reliable, peer-reviewed QSAR prediction model (USEPA 2010). 1,3-divinyl-1,1,3,3-tetramethyldisiloxane is considered not readily biodegradable.

Reference 2

Endpoint:

biodegradation in water: ready biodegradability

Data waiving:

study technically not feasible

Justification for data waiving:

the study does not need to be conducted because the substance is inorganic

Description of key information

Biodegradation is not relevant for inorganic substances and this substance is a solution of an inorganic salt. Therefore, only the biodegradability of the organic component of this substance is reported. The organic component, 1,3-diethenyl-1,1,3,3-tetramethyldisiloxane, is predicted to be not readily biodegradable.

Additional information

Biodegradation is not relevant for inorganic substances and this substance is a solution of an inorganic salt. Therefore, only the biodegradability for the organic component of this substance is reported. The biodegradability of the organic component, 1,3-diethenyl-1,1,3,3-tetramethyldisiloxane, is taken from Biowin, a reliable, peer-reviewed QSAR prediction model (USEPA 2010). The organic component, 1,3-diethenyl-1,1,3,3-tetramethyldisiloxane is predicted to be not readily biodegradable.