Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 813-556-1 | CAS number: 78366-85-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The toxicity of 1,3,5-Tris-(3-mercaptopropyl)isocyanurate was tested according to OECD guidelines 201, 202, and 203 for acute toxicity studies with algae (Pseudokirchneriella subcapitata), aquatic invertebrates (Daphnia magna), and fish (Gobiocypris rarus).
Toxic effects to all three species were determined as following:
96-h LC50(G. rarus) = 0.05 mg/L [95 % C.I.: 0.04 to 0.06 mg/L]
72-h ErC50 (P. subcapitata) = 1.26 mgL [95 % C.I. = 0.97 – 1.63 mg/L]
48-h EC50 (D. magna) = 2.83 mg/L [95 % C.I.: 2.30 to 3.55 mg/L]
As the substance was not stable over the time of exposure, all effect values are reported based on measured concentrations of the parent molecule.
Additional information
Toxicity to invertebrates:
Daphnia magna Straus was exposed for 48 hours to 1,3,5-Tris-(3-mercaptopropyl)isocyanurate in a semi-static short-term toxicity study according to the OECD guideline 202 (2004) and in compliance with the OECD-GLP principles. The test concentrations were determined analytically by LC-ESI-MS/MS. A potential degradation product was discovered though could not be determined or quantified. As the measured test item concentrations are not within ± 20 % of the nominal loading rate, according to OECD 202 (2004) and OECD 23 (2000), all results are given in relation to the analytically measured test item concentrations. Based on the immobilisation of the daphnids the following effect values were derived:
48-h EC50= 2.83 mg/L [95 % C.I.: 2.30 to 3.55 mg/L]
48-h EC10= 1.45 mg/L [95 % C.I.: 1.05 to 1.82 mg/L]
48-h NOEC = 0.57 mg/L
48-h LOEC = 2.06 mg/L
Toxicity to algae:
The freshwater algae Pseudokirchneriella subcapitata was exposed to 1,3,5-Tris-(3-mercaptopropyl)isocyanurate for 72 hours in a static toxicity study according to the OECD guideline 201 (2006) and in compliance with the OECD-GLP principles. The test concentrations were determined analytically by LC-ESI-MS/MS. A potential degradation product was discovered though could not be determined or quantified. As the measured test item concentrations are not within ± 20 % of the nominal loading rate, according to OECD 202 (2004) and OECD 23 (2000), all results are given in relation to the analytically measured test item concentrations. Based on the growth rate of the algae the following effect values were derived:
72-h ErC50= 1.26 mg/L [95 % C.I. = 0.97 – 1.63 mg/L]
72-h ErC10= 0.33 mg/L [95 % C.I. = 0.26 – 0.41 mg/L]
72-h NOErC = 0.15 mg/L
72-h LOErC = 0.51 mg/L
During the pre-tests for the studies with Daphnia magna and Pseudokirchneriella subcapitata, an unknown potential degradation product (probably an oxidation product of the test item, according to the sponsor) with a similar mass as the test item was observed as a second peak in the chromatogram diluting directly after the test item. This potential degradation product was not identified until this study was conducted. The potential degradation product could not be identified (additional equipment, resources and experience with regards to the behavior of the test item in the test solution (e.g. kinetics) would be required), the results are therefore based on the parent molecule.
Toxicity to fish:
Gobiocyprus rarus individuals were exposed for 96 hours to 1,3,5-Tris-(3-mercaptopropyl)isocyanurate in a semi-static short-term toxicity study according to the OECD guideline 203 (1992) and in compliance with the OECD-GLP principles. The test concentrations were determined analytically by LC-MS/MS. A potential degradation product was discovered though could not be determined or quantified. As the measured test item concentrations are not within ± 20 % of the nominal loading rate, according to OECD 203 (1992) and OECD 23 (2000), all results are given in relation to the analytically measured test item concentrations. Based on the mortality of the fish the following effect values were derived:
96-h LC0= 0.026 mg/L
96-h LC50= 0.05 mg/L [95 % C.I.: 0.04 to 0.06 mg/L]
96-h LC100= 0.18 mg/L
As the test item is not rapidly dissolved in water or medium resp., the Fish, Acute Toxicity Study was conducted applying a solubilizing agent: Dimethylformamide (DMF). This study reported also a possible oxidation of the parent compound. Analytical qualification or quantification of the degradation product was not possible in all present studies.
The most sensitive effect value was derived in the Fish, Acute Toxicity test with a 96 -h LC50 of 0.05 mg/L. Based on this value the test item is classified as Aquatic Acute 1 and Aquatic Chronic 1 according to CLP regulation (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.