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Diss Factsheets
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EC number: 473-370-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 February 2007 to 19 March 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2600 (Skin Sensitisation)
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- -
- EC Number:
- 473-370-8
- EC Name:
- -
- Cas Number:
- 13304-62-6
- Molecular formula:
- C10 H11 N O
- IUPAC Name:
- N-benzylprop-2-enamide
1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Charles River France, Larbresle Cedex, France
- Strain: CBA(inbred, SPF quality)
- Females nulliparous and non-pregnant: yes
- Age at study initiation: ca 11 weeks
- Weight at study initiation: 20-26 g
- Housing: Individual (Macrolon MI) saw dust bedding
- Diet: Pelleted Rodent Diet ad libitum (SM R/M-Z SSNIFF Soest Germany)
- Water: tap water ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19.6-23.3 ˚C
- Humidity (%): 39-63%
- Air changes (per hr): ca 15/h
- Photoperiod (hrs dark / hrs light): 12/12
Study design: in vivo (LLNA)
- Vehicle:
- dimethylformamide
- Concentration:
- 10, 25 and 50%
- No. of animals per dose:
- 5 females
- Details on study design:
- PRE-SCREEN TESTS: 1 male/concentration
- Concentrations: 50% (maximum technically possible), 25%
- Irritation: none
- Systemic toxicity: none
- Ear thickness measurements: not performed
- Erythema scores: 0
MAIN STUDY : concentrations selected 10, 25 and 50%
- Statistics:
- NA
Results and discussion
- Positive control results:
- Test with Alpha-Hexylcinnamic Aldehyde tech 85% (5, 10 and 25% in acetone/olive oil (4/1)) was performed in Sepetmber 2006.
SI 6.2, EC3 13.1%
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Value:
- 0.5
- Test group / Remarks:
- 10%
- Parameter:
- SI
- Value:
- 0.6
- Test group / Remarks:
- 25%
- Parameter:
- SI
- Value:
- 0.6
- Test group / Remarks:
- 50%
- Parameter:
- EC3
- Value:
- > 50
- Cellular proliferation data / Observations:
- CLINICAL OBSERVATIONS:
none
BODY WEIGHTS: within expected ranges
ERYTHEMA/OEDEMA: none
LYMPHNODES SIZE: within normal ranges
LYMPHNODES ABNORMALITIES: none
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance is not sensitizing to the skin
- Executive summary:
In a local lymphnode assay the dorsal ear of 5 females was treated with the substance at 10, 25 and 50% concentrations in dimethylformamide. After an injection on day 6 with 3H-methylthymidine, animals were killed, the lymphnodes were excised and investigated for abnormalities. Radioactivity of the lymphnodes (pooled per animal) was assessed by scintillation counting.
No increase of radioactivity compared to vehicle controls was observed. SI values were 0.5, 0.6 and 0.6 at 10, 25 and 50%. The EC3 value is > 50%.
The substance is not considered to be sensitizing to the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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