Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 427-440-1 | CAS number: 24487-91-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 April 1996 - 14 May 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to GLP in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-5 (Acute Dermal Irritation)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.4470 (Acute Dermal Irritation)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Japan 59 NohSan No. 4200
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 427-440-1
- EC Name:
- -
- Cas Number:
- 24487-91-0
- Molecular formula:
- C9H9ClO2
- IUPAC Name:
- 2-Methyl-3-methoxy benzoyl chloride
- Test material form:
- other: solid
- Details on test material:
- MMBC
Appearance: Tan Solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazleton Research Animals, Denver, PA.
- Age at study initiation: approximately 29 weeks.
- Weight at study initiation: 3662 g.
- Housing: The animal was individually housed in a stainless steel cage (18 x 24 x 14.5 in., i.e. 46 x 61 x 37 cm) suspended above an absorbent-paper pan liner which was changed 3 times per week.
- Diet (e.g. ad libitum): approximately 125 g/day of PMI Certified High Fiber Rabbit Diet 5325 (Purina Mills Inc., Richmond, IN).
- Water (e.g. ad libitum): ad libitum filtered tap water (via automatic watering).
- Acclimation period: approximately 2 weeks.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 21 °C
- Humidity (%):44 - 55 %
- (hrs dark / hrs light): 12 hours light, 12 hours darkness.
IN-LIFE DATES: From: To: 30 April 1996 - 14 May 1996
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- 0.5 g, moistened with 0.5 mL distilled water (1:1 w/v).
- Duration of treatment / exposure:
- 4 hours.
- Observation period:
- 14 days.
- Number of animals:
- 1
- Details on study design:
- DOSE PREPARATION AND ADMINISTRATION
Approximately 24 hr prior to application of the test substance, the hair around the entire trunk between the flank and shoulders was shaved closely with electric clippers. The test substance (0.5 g) was moistened with 0.5 mL of distilled water (1:1 w/v), was applied onto a (1.0-in.) square gauze-lined adhesive bandage which was then applied to the shaved intact skin of the rabbit. A semi-occluded dressing (i.e., fabric cuff secured with adhesive tape) was used to wrap the entire trunk of the animal. The rabbit was returned to its cage for a 4 hour exposure period. The cuff and patch were removed after the 4-hr exposure and the application site wiped with a paper towel saturated with tap water. The application site was blotted dry with paper towels.
OBSERVATIONS AND DETERMINATIONS
Skin irritation was evaluated at approximately 1, 24, 48, and 72 hrs and at 7 and 14 days after patch removal. The degree of irritation was evaluated according to the criteria of Draize (see below). In addition, all other skin reactions or signs of systemic toxicity were recorded. The animal was observed daily for mortality and signs of morbidity.
Skin Irritation Scoring (Draize Criteria)
Erythema Scores (maximum = 4)
No erythema 0
Very slight erythema (barely perceptible) 1
Well-defined erythema 2
Moderate to severe erythema 3
Severe erythema (beet redness) oto slight eschar formation (injuries in depth) 4
Oedema Scores (maximum = 4)
No oedema 0
Very slight oedema (barely perceptible) 1
Slight oedema (edges of area well-defined by definite raising) 2
Moderate oedema (edges raised approximately 1 millimetre) 3
Severe oedema (raised more than 1 millimetre and extending beyond the area of exposure) 4
Skin irritation was categorized on the basis of the 1, 24, 48 and 72-hr primary irritation index (PII). The PII is the sum of the erythema and edema scores divided by the number of observations (4), then divided by the number of animals (1).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: Mean scores at 1, 24, 48 and 72 hours
- Score:
- 8
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Severe erythema and oedema as well as blanching with a blackened perimeter were observed at 1 hr and persisted through day 7. The Primary Irritation Index (PII) was 8.0. Deep ulceration was observed on day 14. Skin irritation effects and observations recorded by a veterinary pathologist included (but were not limited to): deep ulceration which extended into the subcutis, and perimeter red with a wide zone of mild to moderate subcutaneous oedema. Additional skin irritation effects are shown in Table 1. These effects were indicative of irreversible destruction of dermal tissue.
- Other effects:
- No mortality or clinical signs of systemic toxicity (other than skin effects) were observed during the study.
Any other information on results incl. tables
Table 1 Skin Irritation Scores
|
Time after patch removal |
|||||
1 hour |
24 hours |
48 hours |
72 hours |
7 days |
14 days |
|
Erythema Score |
4*† |
4*† |
4*† |
4*† |
4*† |
4‡ |
Oedema Score |
4 |
4 |
4 |
4 |
3 |
4 |
* Blanching
† Perimeter of application site: blackened
‡ Ulceration and irreversible destruction of dermal tissue confirmed by veterinary pathologist
PII
Erythema total scores = 16
Oedema total scores = 16
Overall sum = 32, therefore PII = 8.0
Applicant's summary and conclusion
- Interpretation of results:
- Category 1C (corrosive)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- When applied to the shaved intact skin of one male rabbit for 4 hrs, the test substance produced effects indicative of corrosivity (i.e., Irreversible destruction of dermal tissue).
- Executive summary:
The skin irritation potential of the test substance was determined in accordance with standardised guidelines OECD 404, EPA OPP 81 -5, EPA OPPT 798.4470, EU Method B.4 and Japan 59 NohSan No 4200. During the study the test material was seen to produce effects indicative of corrosivity (i.e., irreversible destruction of dermal tissue) when applied to the shaved intact skin of one male rabbit for 4 hrs. Under the conditions of the study, the test material is considered to be corrosive to the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.