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EC number: 238-056-5 | CAS number: 14205-39-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 January 2000 - 9 March 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 1984 Part 1
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- 1992
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Test item code: LZ937.00
Expiration date: 21 May 2000
Delivery date: 11 October 1999
Test material was stored at ambient temperature in the dark.
Physical state: White crystalline solid
Storage conditions: Stored at ambient temperature in the dark - Analytical monitoring:
- yes
- Vehicle:
- no
- Remarks:
- water
- Details on test solutions:
- Test solutions were prepared from a 1000 p.p.m. stock solution. The 1000 p.p.m. stock solution was prepared by adding a weighed amount of LZ937 (249.5 mg) to a 250 ml volumetric flask and bringing to volume with Daphnia medium. The stock solution was ultrasonicated for ca 5-10 min to ensure dispersion/solubility. Serial dilutions of this stock were then made with Daphnia medium to produce the required test concentrations.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna (water flea) used in this study are continuously cultured inhouse by acyclical parthenogenesis. At initiation of exposure neonates were between 6 and 24 h old. Daphnia cultures were maintained in a synthetic
medium as used in the test. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Post exposure observation period:
- 24 h
- Hardness:
- 146 mg CaCO3
- Test temperature:
- 20°C - 21.3°C
- pH:
- between 8.32 and 8.69
- Dissolved oxygen:
- between 87% and 93.2%
- Salinity:
- not applicable
- Conductivity:
- between 478 µs and 608 µs
- Nominal and measured concentrations:
- Nominal 100 p.p.m.
- Details on test conditions:
- Test vessels were maintained in a temperature-controlled laboratory between 22 and 23°C during the definitive test. A light cycle of 16 h light and 8 h dark was in operation throughout the exposure and culture periods. Fluorescent tubes provided artificial daylight illumination. The temperature was recorded at a maximum of 23°C during the test, exceeding 22°C stated in the protocol. This deviation did not affect the validity of the test.
- Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- After 24h exposure, 10 (100%) immobile Daphnia neonates at 1000 ppm and 1 (10%) immobile neonate at 100 p.p.m were observed. No further immobile Daphnia neonates were observed for any concentration in this test after 48 h. The 48 h static limit test was conducted at nominal whole product concentration of 100 p.p.m. with an untreated control (0 ppm). No significant numbers of immobile Daphnia were recorded during the study. A single neonate (5%) was observed in the limit test after 24 h exposure. This low level of effect is not regarded to be indicative of a test material effect.
- Results with reference substance (positive control):
- not applicable
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48h EC50 is >100 mg/L based on nominal concentrations.
- Executive summary:
The study was conducted to determine the acute toxicity (EC50) of LZ937 to the aquatic invertebrate Daphnia magna. The study was conducted under static conditions for 48 h, in accordance with OECD Guideline 202 and EC Guideline C2. A preliminary range finding study indicated that LZ937 was of low toxicity to neonates of Daphnia magna, at a concentration up to 1000 p.p.m. the maximum test concentration tested. A limit study was then conducted at 100 p.p.m. nominal, of LZ937. No significant effects (immobilisation) were observed in the limit study, in either the test or control groups. A single neonate (5%) was observed to be immobile in one test vessel at 24 hours. This is not regarded as an effect of the test material. Throughout the study all test solutions were clear and colourless indicating full dissolution or dispersion of LZ937 in the test medium. The results of this study are based on nominal concentrations.
The results were: 24 and 48h EC50 >100 mg/L nominal of LZ937 and NOEC 100 mg/L nominal of LZ937: Determination of an analytical method was possible.
Reference
All test solutions were clear and colourless. No precipitation of test material was observed. This indicates full dispersion or dissolution of the test material in the test medium. All results are based on nominal concentrations in the absence of analytical results.
Description of key information
The study was conducted under static conditions for 48 h, in accordance with OECD Guideline 202 and EC Guideline C2. A preliminary range finding study indicated that LZ937 was of low toxicity to neonates of Daphnia magna, at a concentration up to 1000 p.p.m. the maximum test concentration tested. A limit study was then conducted at 100 ppm nominal, of LZ937. No significant effects (immobilisation) were observed in the limit study, in either the test or control groups. The results of this study are based on nominal concentrations: 24 and 48h EC50 >100 mg/L nominal of LZ937 and NOEC 100 mg/L nominal of LZ937.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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