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Diss Factsheets
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EC number: 437-760-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From July 29 to September 6, 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- This study was performed according to OECD Guideline 121 and EU Method C.19 with GLP statement. This study is well documented and all validity criteria were fulfilled.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- UK GLP Compliance Programme (inspected on April 12, 2005/ signed on June 01, 2005)
- Type of method:
- HPLC estimation method
- Media:
- soil
- Specific details on test material used for the study:
- PHYSICO-CHEMICAL PROPERTIES
- Vapour pressure: 0.098 Pa at 25 °C
- Relative density: 1.07
- Surface tension: 46.5 mN/m (90% saturated solution)
- Auto-ignition temperature: None below 400 °C
- Oxidising properties: Non-oxidising
- Explosive properties: Not explosive - Radiolabelling:
- no
- Test temperature:
- 25 °C
- Details on study design: HPLC method:
- EQUIPMENT & MOBILE PHASE
Instrument: Hewlett Packard 1050 Liquid Chromatograph
Column: Hypersil H5CPS (25 cm x 4.6 mm internal diameter)
Column temperature: 25°C
Mobile phase composition: Methanol:water (55:45 v/v)
Flow rate: 1.0 mL/min
Injection volume: 10 µL
Detector: UV set at 220 nm
DETERMINATION OF DEAD TIME
- An internal standard (formamide) with no retention on the HPLC column was used to determine the deadtime of the HPLC system.
REFERENCE SUBSTANCES
- Formamide (Internal deadtime standard)
- Acetanilide
- Nitrobenzene
- Naphthalene
- 2-Methylnaphthalene
- Anthracene
- DDT
DETERMINATION OF RETENTION TIMES
- Formamide (Internal deadtime standard), Log10Koc not applicable (deadtime only), Conc. 796 mg/L
- Acetanilide, Log10Koc 1.25, Conc. 20.5 mg/L
- Nitrobenzene, Log10Koc 2.36, Conc. 21.3 mg/L
- Naphthalene, Log10Koc 2.75, Conc. 2.12 mg/L
- 2-Methylnaphthalene, Log10Koc 3.87, Conc. 1.96 mg/L
- Anthracene, Log10Koc 4.41, Conc. 39.2 mg/L
- DDT, Log10Koc 5.63, Conc. 82.6 mg/L
REPETITIONS
- Number of determinations: 2
EVALUATION
- Calculation of capacity factors k: t’r / to = (tr – to) / to
- Determination of the log Koc value: Log10Koc = 2.81 Log10k + 4.02 - Analytical monitoring:
- yes
- Details on sampling:
- see above
- Details on matrix:
- not applicable
- Details on test conditions:
- not applicable
- Key result
- Type:
- log Koc
- Value:
- 2.7 dimensionless
- Temp.:
- 25 °C
- Key result
- Type:
- Koc
- Value:
- 510 L/kg
- Temp.:
- 25 °C
- Details on results (HPLC method):
- See the "Attached background material section" for information on table of results
- Statistics:
- None
- Validity criteria fulfilled:
- yes
- Conclusions:
- Koc = 510 L/Kg ; log Koc = 2.7.
- Executive summary:
The determination of the adsorption coefficient of the test material was performed according to the OECD Guideline No. 121/ EU Method C. 19 with GLP statement.
The experimental method uses HPLC for the estimation of the adsorption coefficient Koc in soil. An analytical column Hypersil H5CPS (25 cm x 4.6 mm internal diameter) was used, with a column temperature at 25 °C. The mobile phase was methanol: water (55:45 v/v). The test item was prepared in mobile phase (18.7 mg/L). The dead time was determined by measuring the retention time of formamide, diluted in mobile phase. The following reference mixture was prepared in HPLC mobile phase: Acetanilide, Nitrobenzene, Naphthalene, 2-Methylnaphthalene, Anthracene and DDT. A solution of test item (18.7 mg/L in mobile phase) was prepared and chromatographed in duplicate, bracketed by samples of the reference mixture, using the HPLC.
In the present study, the reference items covered the range of log Koc 1.25 to 5.63.
Under the conditions of the test, the retention time of the test item was found at 4.340 min for the first injection and at 4.328 min for the second injection. The corresponding log Koc was 2.7 (Koc = 510 L/Kg).
Reference
None
Description of key information
OECD Guideline 121, GLP, key study, validity 1:
Koc = 510 at 25 °C
LogKoc = 2.7 at 25°C
Key value for chemical safety assessment
- Koc at 20 °C:
- 510
Additional information
The determination of the adsorption coefficient of the test material was performed according to the OECD Guideline No. 121/ EU Method C. 19 with GLP statement.
The experimental method uses HPLC for the estimation of the adsorption coefficient Koc in soil. An analytical columnHypersil H5CPS (25 cm x 4.6 mm internal diameter) was used, with a column temperature at 25 °C. The mobile phase was methanol: water (55:45 v/v). The test item was prepared in mobile phase (18.7 mg/L). The dead time was determined by measuring the retention time of formamide, diluted in mobile phase. The followingreference mixture was prepared in HPLC mobile phase: Acetanilide, Nitrobenzene, Naphthalene, 2-Methylnaphthalene, Anthracene and DDT.A solution of test item (18.7 mg/L in mobile phase) was prepared and chromatographed in duplicate, bracketed by samples of the reference mixture, using the HPLC.
In the present study, the reference items covered the range of log Koc 1.25 to 5.63.
Under the conditions of the test, the retention time of the test item was found at 4.340 min for the first injection and at 4.328 min for the second injection. The corresponding log Koc was 2.7 (Koc = 510).
[LogKoc: 2.7]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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