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Diss Factsheets
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EC number: 208-883-6 | CAS number: 544-92-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Copper cyanide
- EC Number:
- 208-883-6
- EC Name:
- Copper cyanide
- Cas Number:
- 544-92-3
- Molecular formula:
- CCuN
- IUPAC Name:
- λ¹-copper(1+) iminomethanide
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 g
- Duration of treatment / exposure:
- The test substance was applied once and was held for 1 second.
- Observation period (in vivo):
- In initial test, cornea, iris and conjunctivae were evaluated on 1 hour and 1-3 days after administration.
In confirmatory test, iris and conjunctivae were evaluated on 1 hour and 1-4 days after administration. - Number of animals or in vitro replicates:
- 1 (Initial test)
3 (Confirmatory test)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.44
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Irritant / corrosive response data:
- Initial test:
Redness of conjunctivae, secreta and chemosis were observed in 1 - 24 hours after administration. Corneal opacity and iris change were not observed.
Control site was no eye irritation.
Confirmatory test:
Redness of conjunctivae, chemosis and secreta were observed sporadically in 1 to 72 hours after administration. Comeal opacity and iris change were not observed.
Control site was no eye irritation. - Other effects:
- Clinical Signs:
During the study periods, no treatment-related dead and clinical signs were found.
Body Weights:
No test substance-related body weight changes were detected.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- As the evaluation of the eye reactions, in the initial test redness of conjunctivae, chemosis and secreta were observed in 1 - 24 hours after administration. Comeal opacity and iris change were not observed.
In the confirmatory test redness of conjunctivae, chemosis and secreta was observed sporadically in 1 - 72 hours after administration. Comeal opacity and iris change were not observed.
No eye irritation was found from control site, (initial test, confirmatory test). In case of confirmatory test, ocular irritation index of Comeal opacity and iris were 0. The ocular irritation index of redness of conjunctivae and chemosis were 0.33, 0.44 respectively. The result of control site was zero.
Based on the results of this study , eye irritation / corrosion ofthe test substance Copper cyanide(Copper(I) cyanide) in New Zealand White Rabbits was verified non-irritation / non¬corrosion substance.
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