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EC number: 223-211-1 | CAS number: 3770-97-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Buffers:
- pH 4:
21.01 g citric acid monohydrate was dissolved in 200 ml sodium hydroxide solution (c = 1 mol/l). This solution was filled up to a volume of 1000 ml with demineralized water. 44 ml of hydrochloric acid (c = 1 mol/l) was added to 560 ml of this solution and filled up to a volume of 1000 ml with demineralized water. The pH value of the buffer solution was adjusted to pH 4 for each hydrolysis temperature.
pH 7:
13.61 g potassium dihydrogen phosphate was dissolved in 1000 ml demineralized water. 30 ml of sodium hydroxide solution (c = 1 mol/l) was added to 500 ml of this solution and filled up to a volume of 1000 ml with demineralized water. The pH of the buffer solution value was adjusted to pH 7 for each hydrolysis temperature.
pH 9:
7.46 g potassium chloride and 6.18 g boric acid were dissolved in 1000 ml demineralized water. 21 ml of sodium hydroxide solution (c = 1 mol/l) was added to 500 ml of this solution and filled up to a volume of 1000 ml with demineralized water. The pH value of the buffer solution was adjusted to pH 9 for each hydrolysis temperature. - Preliminary study:
- The water solubility of the test item is 4.4 g/l (see report PS20170329-4). Solutions of the test item were prepared by dissolving the test item in acetonitrile. These solutions were filled up to 50 ml with the relevant buffers.
Amount of test item /mg at different pH:
pH 4 18.8 Test item precipitated after addition of buffer solution
pH 7 25.4 Test item precipitated after addition of buffer solution
pH 9 13.1 est item precipitated after addition of buffer solution
For a hydrolysis study it is necessary to trace the hydrolysis down to 10 % of the initial weight of the test item. Therefore at least the tenfold amount of the detection limit has to be dissolved in the relevant buffer solution. For this test item the detection limit was determined to be 0.85 mg/l (see chapter 4.4.2). However using the tenfold amount of the detection limit led to precipitation of the test item after addition of the relevant buffer solution. Therefore the hydrolysis test was not feasible. - Transformation products:
- not measured
- Key result
- Remarks on result:
- not determinable because of methodological limitations
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Using the tenfold amount of the detection limit led to precipitation of the test item after addition of the relevant buffer solution. Therefore, the hydrolysis test was not feasible.
Reference
Description of key information
Using the tenfold amount of the detection limit led to precipitation of the test item after addition of the relevant buffer solution. Therefore, the hydrolysis test was not feasible.
Key value for chemical safety assessment
Additional information
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