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EC number: 233-937-0 | CAS number: 10450-60-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08 June 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Version / remarks:
- 2009
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- Laser scattering/diffraction
- Mass median aerodynamic diameter:
- 3 291 µm
- Geometric standard deviation:
- 0.011
- Key result
- Percentile:
- D10
- Mean:
- 1 080 µm
- St. dev.:
- 30.1
- Key result
- Percentile:
- D50
- Mean:
- 1 790 µm
- St. dev.:
- 10.5
- Key result
- Percentile:
- D90
- Mean:
- 2 760 µm
- St. dev.:
- 10.5
- Conclusions:
- Under the conditions of this study, the MMAD (mass median aerodynamic diameter) of the test material was 3291 µm, the d10, d50 and d90 values were 1080, 1790 and 2760 µm, respectively. 0.00 % of the test material sample was < 10.00 µm.
- Executive summary:
The particle size distribution of the test material was investigated in accordance with the standardised guideline ISO 13320, under GLP conditions.
Following optical microscope analysis and solubility and dispersability tests the laser diffraction analysis was conducted using the small volume (wet) module (SVM) with silicone oil as the dispersant.
Under the conditions of this study, the MMAD (mass median aerodynamic diameter) of the test material was 3291 µm, the d10, d50 and d90 values were 1080, 1790 and 2760 µm, respectively. 0.00 % of the test material sample was < 10.00 µm.
Reference
OPTICAL MICROSCOPE ANALYSIS
- Standard visual observation: Sample observed to be a coarse, gritty, free flowing, non-dusting off-white powder.
- Observation using 3.2 objective lens: The particles appeared to be irregular shaped crystals. The smallest individual particle size was approximately 752 μm and the largest individual size was approximately 1888 μm.
- Observation using 40 objective lens: The sample was observed to be made up of single crystalline particles.
PRELIMINARY SOLUBILITY TEST
The sample was well dispersed in silicone oil. For the full solubility and dispersability test silicone oil was selected.
SOLUBILITY AND DISPERSABILITY TEST
The test material sample was well dispersed in the silicon oil at 10 seconds and 30, 60, 90 and 120 minutes.
The sample proved to be insoluble and well dispersed in silicone oil. Silicone oil was therefore used as the dispersant.
LASER DIFFRACTION PARTICLE SIZE ANALYSIS
Table 1: Full Test Results
|
Run 1 |
Run 2 |
Run 3 |
Run 4 |
Run 5 |
Average ** |
Volume weighted mean |
1840 |
1850 |
1860 |
1860 |
1890 |
1860 |
Median |
1780 |
1780 |
1790 |
1790 |
1820 |
1790 |
Mode |
1890 |
1890 |
1900 |
1900 |
1910 |
1900 |
MMAD* |
3259 |
3266 |
3293 |
3289 |
3348 |
3291 |
d10 (10 % of material is <) |
1060 |
1060 |
1090 |
1080 |
1130 |
1080 |
d50 (50 % of material is <) |
1780 |
1780 |
1790 |
1790 |
1820 |
1790 |
d90 (90 % of material is <) |
2750 |
2750 |
2760 |
2760 |
2780 |
2760 |
All results are in μm
* Mass median aerodynamic diameter
** Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.
0.0
Table 2: Standard Deviation results
|
Run 1 |
Run 2 |
Run 3 |
Run 4 |
Run 5 |
STDVP |
% STDVP |
d10 (10 % of material is <) |
1060 |
1060 |
1090 |
1080 |
1130 |
30.1 |
2.78 |
d50 (50 % of material is <) |
1780 |
1780 |
1790 |
1790 |
1820 |
19.2 |
1.07 |
d90 (90 % of material is <) |
2750 |
2750 |
2760 |
2760 |
2780 |
10.5 |
0.380 |
GSD |
1.429 |
1.427 |
1.417 |
1.418 |
1.397 |
0.011 |
0.8 |
MMAD |
3259 |
3266 |
3293 |
3289 |
3348 |
31.460 |
1.0 |
GSD = Geometric standard deviation of the lognormal particle size distribution (calculated from d50/d15.78)
STDVP = standard deviation of the population
% STDVP = percentage standard deviation of the population
- Coefficient of variation for d50 is less than 3 %; d10 and d90 are less than 5 %. Thus repeatability of the characteristic particles in the size distribution are within the acceptable limits as per the ISO 13320-1 test standard.
Description of key information
Livingston (2018)
Under the conditions of this study, the MMAD (mass median aerodynamic diameter) of the test material was 3291 µm, the d10, d50 and d90 values were 1080, 1790 and 2760 µm, respectively. 0.00 % of the test material sample was < 10.00 µm.
Additional information
Livingston (2018)
The particle size distribution of the test material was investigated in accordance with the standardised guideline ISO 13320, under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
Following optical microscope analysis and solubility and dispersability tests the laser diffraction analysis was conducted using the small volume (wet) module (SVM) with silicone oil as the dispersant.
Under the conditions of this study, the MMAD (mass median aerodynamic diameter) of the test material was 3291 µm, the d10, d50 and d90 values were 1080, 1790 and 2760 µm, respectively. 0.00 % of the test material sample was < 10.00 µm.
Read-across to Sodium Periodate
The particle size distribution of the read across substance, sodium periodate, was evaluated in accordance with OECD Guideline 110 under GLP conditions. The study was assigned a reliability score of 1 in accordance with the principles for assessing data quality as outlined by Klimisch et al (1997), however, since the data is available on a read across substance an overall reliability score of 2 is considered appropriate. Sodium periodate is considered to be a suitable substance for read across since it is the sodium salt of periodic acid.
During the study the proportion of a sample that was able to pass through a 100 µm sieve was measured; the proportion of test material having an inhalable particle size of less than 100 µm was determined to be 2.9 %.
Therefore, the test material was considered to be essentially non-inhalable.
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