Dibutyl [[bis[(2-ethylhexyl)oxy]phosphinothioyl]thio]succinate

Endpoint summary

Description of key information

Oral

Key study:

In an acute oral gavage study in male rats performed under conditions similar to the OECD 401 guideline, the LD50 of the test material was 11300 mg/kg.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

11 February 1981 to 04 March 1981

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not specified

GLP compliance:

no

Test type:

acute toxic class method

Limit test:

no

Specific details on test material used for the study:

- Date received: 28 January 1981

Species:

rat

Strain:

other: Sherman-Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

- Housing: The animals were housed and maintained in compliance with the U.S. Animal Welfare Act (Pub. L- 94- 279) 9 CFR Part 3.
- Weight: Between 200 and 300 g.
- Feeding / water: The animals were allowed food and water ad libitum, except that they were deprived of food overnight prior to dosing.

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

1.0, 2.0, 4.0, 8.0 and 16.0 g/kg

No. of animals per sex per dose:

Five

Control animals:

no

Details on study design:

- 14 day observation period

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

11.3 other: g/kg

Based on:

test mat.

95% CL:

> 7.7 - < 16.7

Mortality:

No mortality was observed in the 1.0, 2.0 and 4.0 g/kg dose groups. One death occurred in the 8.0 g/kg dose group and 4 mortalities were observed in the 16.0 g/kg dose group, where the deaths occurred after 3-4 hours. The sole surviving animal remained in poor health for 3 days before recovering.

Clinical signs:

other: No unusual signs were noted at 1.0, 2.0 and 4.0 g/kg. The 8.0 g/kg, the animals appeared depressed, ruffled and slightly ataxic within 3-4 hours dosing. Animals at 16.0 g/kg were severely depressed, ruffled, dirty, drooling and ataxic within 2 hours after

Gross pathology:

Gross pathologic examination revealed nothing remarkable relating to test material administration.

Interpretation of results:

GHS criteria not met

Conclusions:

The acute oral of the test material was LD50 of 11300 mg/kg,

Executive summary:

In an acute oral gavage study in male rats performed under conditions similar to the OECD 401 guideline, the LD50 of the test material was 11300 mg/kg.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Value:

11 300 mg/kg bw

Quality of whole database:

1

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no study available