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EC number: 211-238-1 | CAS number: 635-51-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-03-02 - 2018-03-21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 430 (In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Phenylsuccinic acid
- EC Number:
- 211-238-1
- EC Name:
- Phenylsuccinic acid
- Cas Number:
- 635-51-8
- Molecular formula:
- C10H10O4
- IUPAC Name:
- 2-phenylbutanedioic acid
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- Molecular formula:
C10H10O4
Molecular Mass:
194.18
Characteristics (Physical Appearance):
White crystalline powder
Characteristics (Physical Appearance):
White Crystalline powder
CAS No.:
635-51-8
Batch Number:
123
Purity:
100%
In vitro test system
- Test system:
- isolated skin discs
- Source species:
- rat
- Cell type:
- non-transformed keratinocytes
- Cell source:
- foreskin from multiple donors
- Source strain:
- Wistar
- Details on animal used as source of test system:
- Species:
Rat (Rattus norvegicus)
Strain:
Wistar
Justification of selection:
Rat is the rodent species and Wistar is the strain recommended by the test guideline.
Source:
Bred and reared at INTOX PVT. LTD.
Age at start of study:
22 days
No. of animals and sex:
10 males
Environmental conditions:
The experimental animal room was supplied with fresh and filtered air, with 10 to 15 air changes per hour. The room was air conditioned with temperature between 19 to 25 oC, relative humidity 30 to 70% and illumination cycle set to 12 hours light and 12 hours dark. - Vehicle:
- water
- Control samples:
- yes, concurrent vehicle
- yes, concurrent positive control
- Amount/concentration applied:
- 150 mg + 150 μL Analytical Grade Water
- Duration of treatment / exposure:
- 24 hours
- Number of replicates:
- 3
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- transcutaneous electrical resistance (in kΩ)
- Run / experiment:
- test item
- Value:
- 12.87
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Irritation / corrosion parameter:
- transcutaneous electrical resistance (in kΩ)
- Run / experiment:
- solvent control
- Value:
- 15.83
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Irritation / corrosion parameter:
- transcutaneous electrical resistance (in kΩ)
- Run / experiment:
- positive control
- Value:
- 0.78
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to the criteria of acceptance, under the experimental conditions of the study 'In-Vitro Skin Corrosion Study by Transcutaneous Electrical Resistance Test Method (TER) of 2-Phenylsuccinic Acid it is concluded that the test item 2-Phenylsuccinic Acid is considered as non-corrosive to rat skin as per the United Nations(UN) Globally Harmonised System (GHS) for classification of chemicals.
- Executive summary:
In-Vitro Skin Corrosion Study by Transcutaneous Electrical Resistance Test Method (TER) of 2-Phenylsuccinic Acid was carried out in compliance with the Organization for Economic Co-operation and Development (OECD) Guidelines for Testing of Chemicals, Section 4, No. 430 - In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER), adopted by the council on 26 July 2013.
The mean TER value obtained for test item 2-Phenylsuccinic Acid was 12.87 K Ω (which was greater than 5 k Ω) and the skin discs showed no obvious damage (e.g. perforation). The mean disc dye content was 55.14 μg/disc, which was lesser than the mean disc dye content of the 10M HCl positive control obtained concurrently.
According to the criteria of acceptance, under the experimental conditions of the study 'In-Vitro Skin Corrosion Study by Transcutaneous Electrical Resistance Test Method (TER) of 2-Phenylsuccinic Acid it is concluded that the test item 2-Phenylsuccinic Acid is considered as non-corrosive to rat skin as per the United Nations(UN) Globally Harmonised System (GHS) for classification of chemicals.
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