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EC number: 244-121-9 | CAS number: 20941-65-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 Jun 2017 to 14 Feb 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- validation criteria were nto met due to chelation or metal exchange of the test item
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- July 1995
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): (tetrakis(diethyldithiocarbamato-S,S')tellurium
- Batch No: 60700109
- Purity: 99.0%
- Date of reception in the test facility: 27 February 2017
- Expiration date of the test item: 14 July 2018
- Appearance: yellow powder
- Storage conditions: well-ventilated place, ambient temperature and obscurity - Key result
- Water solubility:
- 0.634 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- >= 1.7 - <= 24.6 h
- Temp.:
- 20.5 °C
- pH:
- >= 4.7 - <= 5.3
- Details on results:
- The water solubility of the test item was calculated as the mean of the concentrations determined at both 12.5 mL/h flow rates. The value obtained was 0.634 mg/L. The temperature in column #1 test ranged from 20.3 - 22.4 C° (mean: 20.5 °C). The temperature in column #2 test ranged from 20.4 - 20.5 C° (mean: 20.5 °C). All samples were between pH 4.7 and 5.3.
The repeatability of the analysis has shown high variability as many % Relative Standard Deviation (RSD) are far from the maximum acceptable tolerance (i.e. 20%). It is well-known that dithiocarbamates exhibit a high propensity to chelate or exchange metal ions (i.e. Tellurium in the case of the test item), from the medium, containers, or other analytical equipment’s. This is probably causing the lack of robustness of the method (random signal response over time). Therefore, the data obtained should be taken with caution.
Although the test item concentrations as determined during this study are not fully reliable the following conclusions are proposed:
- Concentration/time curves: Except the results obtained at 25 mL/h flow rate and despite some outliers values these curves show that a saturation plateau was reached by the second sample at all tested flow rates: the test item solubility seems to be between 0.3 and 0.9 mg/L.
- Column test #1: The solubility measured was clearly higher with the lower flow rate and thus the data obtained with the higher flow rate should be disregarded: the test item concentrations determined at the 25 mL/h flow rate are not used for the final calculations.
- Column test #2 at flow rate 6 mL/h: All % RSD are clearly higher the maximum acceptable tolerance and thus are also disregarded: the test item concentrations determined during both tests carried at 12.5 ml/h are thus used for the final calculations.
- Column test#1 & test #2 at 12.5 mL/h: The test item concentrations for which % RSD is >20% are disregarded.
The test item solubility was thus calculated from determinations of the "retained samples", shown in the first table in 'Any other information on results incl. tables'. The results from all tests are provided in this section as well.
Reference
Table: Test item measurements of the two column tests
Test |
Sample ''retained'’
|
Time (hours) |
Test item concentration (mg/L) |
Standard Deviation |
RSD (%) |
|||
Measure 1 |
Measure 2 |
Measure 3 |
Mean |
|||||
Column test #1 |
#3 |
1.7 |
0.655 |
0.71 |
0.726 |
0.697 |
0.037 |
5.3 |
#4 |
2.8 |
0.716 |
0.845 |
0.822 |
0.794 |
0.069 |
8.7 |
|
#5 |
3.8 |
0.896 |
0.868 |
0.833 |
0.866 |
0.031 |
3.6 |
|
#6 |
4.8 |
0.994 |
0.859 |
0.932 |
0.928 |
0.068 |
7.3 |
|
#8 |
21.9 |
0.718 |
0.61 |
0.608 |
0.646 |
0.063 |
9.8 |
|
#9 |
22.9 |
0.605 |
0.583 |
0.586 |
0.592 |
0.012 |
2.1 |
|
Column test #1 results |
0.754 |
0.131 |
17.4 |
|||||
Column test #2 |
#4 |
20.6 |
0.45 |
0.399 |
0.558 |
0.469 |
0.081 |
17.2 |
#5 |
22.6 |
0.347 |
0.334 |
0.371 |
0.351 |
0.019 |
5.3 |
|
#6 |
24.6 |
0.371 |
0.352 |
0.375 |
0.366 |
0.012 |
3.3 |
|
Column test #2 results |
0.395 |
0.064 |
16.2 |
|||||
Colum test #1 & #2 results |
0.634 |
0.209 |
33 |
RSD: Relative standard deviation
Table: Test Item Determinations (Column Test #1, Flow Rate 25 mL/h)
Sample |
Time (hours) |
Test item concentration (mg/L) |
Standard Deviation |
RSD (%) |
|||
Measure 1 |
Measure 2 |
Measure 3 |
Mean |
||||
#1 |
T0 |
<QL |
<QL |
<QL |
<QL |
NA |
NA |
#2 |
0.9 |
0.129 |
0.135 |
0.153 |
0.139 |
0.012 |
8.9 |
#3 |
1.8 |
0.139 |
0.147 |
0.157 |
0.147 |
0.009 |
6.1 |
#4 |
2.9 |
0.151 |
0.183 |
0.173 |
0.169 |
0.016 |
9.8 |
#5 |
3.9 |
0.181 |
0.166 |
0.169 |
0.172 |
0.008 |
4.6 |
#6 |
4.9 |
0.173 |
0.157 |
0.158 |
0.163 |
0.009 |
5.8 |
#7 |
5.9 |
0.059 |
0.038 |
0.029 |
0.042 |
0.015 |
37 |
#8 |
22 |
0.131 |
0.107 |
0.108 |
0.115 |
0.013 |
11.7 |
#9 |
23 |
0.102 |
0.099 |
0.097 |
0.099 |
0.003 |
2.7 |
#10 |
24 |
0.157 |
0.157 |
0.154 |
0.156 |
0.001 |
0.9 |
#11 |
25 |
0.182 |
0.185 |
0.176 |
0.181 |
0.005 |
2.5 |
< DL (4.01 μg/L): concentration lower than the Detection Limit
< QL (13.4 μg/L): concentration lower than the Quantification Limit
NA: Not Applicable
RSD: Relative Standard Deviation
Table: Test Item Determinations (Column Test #1, Flow Rate 12.5 mL/h)
Sample |
Time (hours) |
Test item concentration (mg/L) |
Standard Deviation |
RSD (%) |
|||
Measure 1 |
Measure 2 |
Measure 3 |
Mean |
||||
#1 |
T0 |
<QL |
<QL |
<QL |
<QL |
NA |
NA |
#2 |
0.8 |
0.141 |
0.15 |
0.163 |
0.151 |
0.011 |
7.2 |
#3 |
1.7 |
0.655 |
0.71 |
0.726 |
0.697 |
0.037 |
5.3 |
#4 |
2.8 |
0.716 |
0.845 |
0.822 |
0.794 |
0.069 |
8.7 |
#5 |
3.8 |
0.896 |
0.868 |
0.833 |
0.866 |
0.031 |
3.6 |
#6 |
4.8 |
0.994 |
0.859 |
0.932 |
0.928 |
0.068 |
7.3 |
#7 |
5.8 |
0.833 |
0.717 |
0.397 |
0.649 |
0.226 |
34.8 |
#8 |
21.9 |
0.718 |
0.61 |
0.608 |
0.646 |
0.063 |
9.8 |
#9 |
22.9 |
0.605 |
0.583 |
0.586 |
0.592 |
0.012 |
2.1 |
< DL (4.01 μg/L): concentration lower than the Detection Limit
< QL (13.4 μg/L): concentration lower than the Quantification Limit
NA: Not Applicable
RSD: Relative Standard Deviation
Table: Test Item Determinations (Column Test #2, Flow Rate 12.5 mL/h)
Sample |
Time (hours) |
Test item concentration (mg/L) |
Standard Deviation |
RSD (%) |
|||
Measure 1 |
Measure 2 |
Measure 3 |
Mean |
||||
#1 |
T0 |
0.013 |
0.014 |
0.014 |
0.014 |
0 |
1.9 |
#2 |
16.6 |
0.613 |
0.435 |
0.373 |
0.473 |
0.125 |
26.4 |
#3 |
18.6 |
0.364 |
0.257 |
0.259 |
0.293 |
0.061 |
20.9 |
#4 |
20.6 |
0.45 |
0.399 |
0.558 |
0.469 |
0.081 |
17.2 |
#5 |
22.6 |
0.347 |
0.334 |
0.371 |
0.351 |
0.019 |
5.3 |
#6 |
24.6 |
0.371 |
0.352 |
0.375 |
0.366 |
0.012 |
3.3 |
#7 |
40.6 |
0.334 |
0.237 |
0.2 |
0.257 |
0.069 |
27 |
#8 |
42.6 |
0.815 |
0.596 |
0.499 |
0.636 |
0.162 |
25.4 |
#9 |
44.8 |
0.86 |
0.421 |
0.31 |
0.53 |
0.291 |
54.9 |
#10 |
46.6 |
0.785 |
0.496 |
0.41 |
0.563 |
0.197 |
34.9 |
#11 |
48 |
0.735 |
0.373 |
0.319 |
0.476 |
0.226 |
47.6 |
< DL (4.01 μg/L): concentration lower than the Detection Limit
< QL (13.4 μg/L): concentration lower than the Quantification Limit
RSD: Relative Standard Deviation
Table: Test Item Determinations (Column Test #2, Flow Rate 6 mL/h)
Sample |
Time (hours) |
Test item concentration (mg/L) |
Standard Deviation |
RSD (%) |
|||
Measure 1 |
Measure 2 |
Measure 3 |
Mean |
||||
#1 |
T0 |
0.041 |
0.048 |
0.048 |
0.045 |
0.004 |
9 |
#2 |
16.1 |
0.871 |
0.506 |
0.423 |
0.6 |
0.238 |
39.7 |
#3 |
20.1 |
0.495 |
0.48 |
0.862 |
0.612 |
0.216 |
35.3 |
#4 |
24.1 |
0.454 |
0.314 |
0.295 |
0.354 |
0.087 |
24.5 |
#5 |
40.1 |
0.447 |
0.248 |
0.205 |
0.3 |
0.129 |
43.1 |
#6 |
44.3 |
2.555 |
1.289 |
0.916 |
1.586 |
0.859 |
54.2 |
#7 |
47.5 |
0.925 |
0.413 |
0.319 |
0.552 |
0.326 |
59.1 |
< DL (4.01 μg/L): concentration lower than the Detection Limit
< QL (13.4 μg/L): concentration lower than the Quantification Limit
RSD: Relative Standard Deviation
VALIDATION CRITERIA
The following guidelines recommendations were not met:
- It was technically not possible to get reliable data from 2 successive runs carried at 2 different flow rates. The test results were thus calculated from 2 runs at the same flow rate of 12.5 mL/h.
- Due to unreliable measurements it was not possible to get at least five consecutive samples taken from the saturation plateau
- The mean values obtained from two tests with identical flows differed by more than 30%
Description of key information
The water solubility of the test item was determined to be 0.634 mg/L at 20.5 °C (mean) and pH 4.7 - 5.3
Key value for chemical safety assessment
- Water solubility:
- 0.634 mg/L
- at the temperature of:
- 20 °C
Additional information
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