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EC number: 257-048-2 | CAS number: 51200-87-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Short-term EC50 and NOEC values for 4,4-Dimethyl-1,3-oxazolidine (CAS no. 51200-87-4) are available for two trophic levels of the aquatic freshwater compartment (aquatic invertebrates, algae) from GLP studies according to EPA guidelines (aquatic invertebrates) and OECD 201 (algae).
Growth inhibition study aquatic algae (Selenastrum capricornutum) (OECD 201, 1984):
ErC50 (72h): 6.57 mg/l nominal concentration
NOErC (72h): 2.5 mg/l nominal concentration
Short term toxicity on invertebrates (Daphnia magna) (U.S. EPA, Ecol. Res. Ser. 660/3-75009, 1975):
LC50 (48h): 45 mg/l estimated concentration (statistical result using a computerized program, moving average test)
Additional information
Algae
Ecotoxicological testing of Bioban CS-1135 (CAS 51200-87-4) was conducted to determine the growth inhibition of the freshwater green alga, Selenastrum capricornutum Printz, according to the OECD Method 201 (Alga, Growth Inhibition Test, 1984) and in general accordance with OPPTS Method 850.5400 (Algal Toxicity, Tiers I and II, 1996).
Results from the range-finding test indicated that the 50% inhibitory effect level and the no effect level for growth inhibition of Selenastrum capricornutum were between 1 and 10 mg/L for all endpoint parameters (72 and 96 -hour cell number, area under growth curve and growth rate).
The available analytical methods for the test item were not able to extract and quantify this compound. Calculations of all statistical endpoints for the definitive test were conducted using nominal concentrations. The 72 and 96 -hour EC50s for cell number were 3.79 and 5.42 mg/L, respectively. The 72 and 96 -hour EC50s for area under the growth curve were 3.76 and 4.20 mg/L, respectively. The 0 to 72 and 0 to 96 -hour EC50s for growth rate were 6.57 and 7.14 mg/L, respectively. The NOEC and LOEC for 72 -hour cell number and area under the growth curve were 1.25 and 2.50 mg/L, respectively. For the other four endpoint parameters, the NOEC and LOEC were 2.50 and 5.00 mg/L, respectively.
Daphnia
Key study
The acute toxicity of the test material to Daphnia magna was assessed using the methods outlined by the Commitee on Methods for Toxicity Tests with Aquatic Organisms (US methods). Water quality parameters of temperature, dissolved oxygen and pH were measured at the termination of the test and were within acceptable limits. The estimated LC50 at 24 hr was 75 (56-100) mg/L and at 48 hr was 45 (32-56) mg/L (95 percent confidence limits in parenthesis). The 48 hr "no effect" level was 32 mg/L.
Supporting study
Further, there is one non-GLP supporting study available for aquatic invertebrates according to EPA guidelines:
Short term toxicity on invertebrates (Daphnia magna) (U.S. EPA suggested guidelines, CFR Vol. 43, Part 163.72-2)
LC50 (48h): 51 mg/l measured concentration (analytical method not specified)
Conclusion on classification
The environmental classification of 4,4-Dimethyl-1,3-oxazolidine (CAS no. 51200-87-4) is currently not harmonised according to the CLP Regulation (EC) 1272/2008. Based on available acute aquatic toxicity data, the lowest valid effect concentration for freshwater aquatic organisms is 6.57 mg/L (ErC50 for algae). Based on the available acute data, the substance should not be classified for acute toxicity following Annex I, table 4.1.0a of the CLP regulation (there are no acute values <=1 mg/L).
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