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Diss Factsheets
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EC number: 212-611-1 | CAS number: 831-82-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Effects on developmental toxicity
Description of key information
- The maternal NOAEL is 50 mg/kgbw/day
- The foetal NOAEL is 200 mg/kgbw/day
- And 4-Phenoxyphenol was not considered to be embryotoxic, fetotoxic or teratogenic in the rat.
As indicated in the read-across justification data from Diphenyl Ether can be used for read-across to 4-Phenoxy Phenol systemic toxicological endpoints.
Therefore, the NOAEL and LOEAL determined in the rat prenatal study (OECD 414) for a mixture of Diphenyl Ether/ Biphenyl can be used for 4-Phenoxyphenol:
Link to relevant study records
- Endpoint:
- developmental toxicity
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
See 2018_Read-across-Justification_V1 in attached justification - Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 50 mg/kg bw/day (nominal)
- Based on:
- other: Diphenyl Ether
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Dose descriptor:
- LOAEL
- Effect level:
- ca. 200 mg/kg bw/day (nominal)
- Based on:
- other: Diphenyl Ether
- Basis for effect level:
- body weight and weight gain
- Key result
- Abnormalities:
- no effects observed
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 500 mg/kg bw/day (nominal)
- Based on:
- other: Diphenyl Ether
- Sex:
- male/female
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Key result
- Abnormalities:
- no effects observed
- Key result
- Developmental effects observed:
- no
- Conclusions:
- As indicated in the read-across justification, data from Diphenyl Ether can be used for read-across to 4-Phenoxy Phenol systemic toxicological endpoints.
Therefore, the NOAEL and LOEAL determined in the rat prenatal study (OECD 414) for a mixture of Diphenyl Ether/ Biphenyl can be used for 4-Phenoxyphenol:
- The maternal NOAEL is 50 mg/kgbw/day
- The maternal LOAEL, based on body weight, is 200 mg/kgbw/day
- And 4-Phenoxyphenol was not considered to be embryotoxic, fetotoxic or teratogenic in the rat. - Executive summary:
As indicated in the read-across justification, data from Diphenyl Ether can be used for read-across to 4-Phenoxy Phenol systemic toxicological endpoints.
Therefore, the NOAEL and LOEAL determined in the rat prenatal study (OECD 414) for a mixture of Diphenyl Ether/ Biphenyl can be used for 4-Phenoxyphenol:
- The maternal NOAEL is 50 mg/kgbw/day
- The maternal LOAEL, based on body weight, is 200 mg/kgbw/day
- And 4-Phenoxyphenol was not considered to be embryotoxic, fetotoxic or teratogenic in the rat.
Reference
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the Prenatal study, 4 -phenoxyphenol does not have to be classified according to the CLP regulation with regard to Reprotoxicity.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.