Registration Dossier
Registration Dossier
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EC number: 700-140-9 | CAS number: 752984-24-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according EU/OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- (1R,2S)-2,6-dimethyl-2,3-dihydro-1H-inden-1-amine
- EC Number:
- 700-140-9
- Cas Number:
- 752984-24-0
- Molecular formula:
- C11H15N
- IUPAC Name:
- (1R,2S)-2,6-dimethyl-2,3-dihydro-1H-inden-1-amine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Doses:
- 300 and 2000 mg/kg body weight (bw)
- No. of animals per sex per dose:
- 3 female rats
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals dosed with 2000 mg/kg bw died during the observation period.
- Clinical signs:
- other: Clinical cramps, tremor, labored breathing, lateral position and gasping.
- Gross pathology:
- The necropsy did not reveal any treatment-related findings.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Executive summary:
Under the conditions of this study the median lethal dose (LD50) of the test item after oral administration was found to be greater than 300 mg/kg bw and less than 2000 mg/kg bw in rats.
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