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EC number: 214-527-0 | CAS number: 1141-38-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 March 2018 - 18 April 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Batch No.of test material:
0012747069
- Expiration date of the lot/batch:
January 24, 2019
- Purity test date:
99.96%
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material:
At ambient temperature
- Stability under test conditions:
stable - Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: All stock solutions and all test concnetrations
- Sample storage conditions before analysis: All samples were stored in amber glass bottles in the dark at a temperature of ≤ -18°C. - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: According to OECD 2000, Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures. (ENV/JM/MONO(2000)6). A stock solution of 100 mg/L was ultrasonicated for 5 min and then stirred for 69 hours and 15 min at ambient temperarue in the dark at 1000 rpm. After setteling, the solution was filtered and the first 150 mL of the filtrate were discarded.
- Evidence of undissolved material: By visual inspection, the filtered stock solution showed no Tyndall effect as an evidence for unsolved test substance - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Clone: M10
- Source: Cultured at the test lab since December 2011
- Age of parental stock: Less than 35 days
- Feeding during test: Daphnids were not fed during the exposure period - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 254 mg/L as CaCO3
- Test temperature:
- 19.8°C
- pH:
- 7.7
- Dissolved oxygen:
- 8.6 mg/L
- Conductivity:
- 674 µS/cm
- Nominal and measured concentrations:
- Nominal: 100, 56.2, 31.6, 17.7, and 10.0 % of a saturated solution at a loading rate of 100 test item/L and a control
Measured: 9.92, 2.92, 9.92 mg/L determined for the nominal concentrations of 100, 31.6 and 10.0 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type: open
- Material, size, headspace, fill volume: 100 mL glass beakers. fill volume 50-60 mg/L per vessel
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
Elendt medium M4
- Alkalinity: 1.0 mmol/L
- Conductivity: 674 µS/cm
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Photoperiod: 16 hours light: 8 hours dark
- Light intensity: 50-1000lx
EFFECT PARAMETERS MEASURED: Immobility, determined daily
VEHICLE CONTROL PERFORMED: no
RANGE-FINDING STUDY
- Results used to determine the conditions for the definitive study: yes - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 9.92 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: No
- Other adverse effects control: No - Reported statistics and error estimates:
- Probit analysis using linear max. likelihood regression.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of the test, the EC50 of 2,6 -Naphthalene dicarboxylic acid to Daphnia magna is higher than the highest test concentration of 9.92 mg/L of the initially measured test concentration.
Reference
Description of key information
Determination of the acute toxicity of 2,6 -Naphthalene dicarboxylic acid to Daphnia magna.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 9.92 mg/L
Additional information
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