2-Propenoic acid, methyl ester, reaction products with 2-ethyl-1-hexanamine and sodium hydroxide

Vapour pressure

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

March 09, 2018 - June 11, 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: isothermal thermogravimetry

Specific details on test material used for the study:

- Composition of test material: Sodium-2-ethylhexyliminomonopropionate and Sodium-2-ethylhexyliminodipropionate
- Analytical purity: >=98%
- Purity test date: 13 December 2017
- Lot/batch No.: WI6K21X06-FD2
- Expiration date of the lot/batch: 05 December 2018
- Appearance: White paste
- Storage: At room temperature

Key result

Temp.:

20 °C

Vapour pressure:

< 0.002 Pa

Remarks on result:

other: 0.000011 mm Hg

Key result

Temp.:

25 °C

Vapour pressure:

< 0.004 Pa

Remarks on result:

other: 0.000030 mm Hg

Weight loss was observed from the start of the study and was due to evaporation of impurities, including residual water. In the range of 30°C and 60°C, non-linear weight loss was observed and the results within this range were therefore not reliable for the determination of the vapour pressure. Since no reliable vapour pressure could be calculated from the results obtained in the range of 30°C and 60°C, the weight losses were compared with the results of naphthalene.Since the weight loss of the impurities was lower than the weight loss of the reference compound, the vapour pressure is considered to be lower than that of naphthalene. For information, the corresponding vapour pressure at 20°C and 25°C was < 7.6 Pa and < 12 Pa, respectively.

From 140°C upwards, reaction and/or decomposition was observed. Therefore weight loss was determined in the range of 100°C and 130°C. Within this range, non-linear weight loss was observed and the results within this range were therefore not reliable for the determination of the vapour pressure. Since no reliable vapour pressure could be calculated from the results obtained in the range of 100°C and 130°C, the weight losses were compared with the results of hexachlorobenzene. Since the weight loss of the test item was lower than the weight loss of the reference compound (except at 100°C), the vapour pressure of the test item is considered to be lower than that of hexachlorobenzene. The corresponding vapour pressure at 20°C and 25°C was < 0.0015 Pa and < 0.004 Pa, respectively.

Conclusions:

The isothermal TGA effusion method was applied for the determination of the vapour pressure of the test item. The vapour pressure of the test item (impurities excluded) at 20°C (293K) and 25°C (298K) was < 0.0015 Pa and < 0.004 Pa, respectively.

Executive summary:

The vapour pressure of the test item was determined in a GLP-compliant study performed in accordance with EU A.4 Method and OECD Guideline No. 104, using the isothermal TGA effusion method. The vapour pressure of the test item (impurities excluded) was < 0.0015 Pa at 20°C and < 0.004 Pa at 25°C.

Reference 2

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

2012-08-27 --> 2012-09-04

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

GLP compliance:

yes

Type of method:

effusion method: by loss of weight or by trapping vaporisate

Temp.:

20 °C

Vapour pressure:

< 0.002 Pa

Temp.:

25 °C

Vapour pressure:

< 0.006 Pa

Conclusions:

The vapour pressure of the test substance was determined to <1.5 mPa at 20°C and <5.8 mPa at 25 °C.

Executive summary:

The vapour pressure of the test substance was determined to <1.5 mPa at 20°C and <5.8 mPa at 25 °C.

Description of key information

The vapour pressure of 2-Propenoic acid, methyl ester, reaction products with 2-ethyl-1-hexanamine and sodium hydroxide (methanol free) was determined in a GLP-compliant study performed in accordance with EU A.4 Method and OECD Guideline No. 104, using the isothermal TGA effusion method. The vapour pressure of the test item (impurities excluded) was < 0.0015 Pa at 20°C and < 0.004 Pa at 25°C.

Key value for chemical safety assessment

Vapour pressure:

0.002 Pa

at the temperature of:

20 °C

Additional information

The vapour pressure of 2-Propenoic acid, methyl ester, reaction products with 2-ethyl-1-hexanamine and sodium hydroxide (methanol free) was determined in a GLP-compliant study performed in accordance with standard methods, without deviations (Volic, 2018). The study is considered as reliable (Klimisch 1) and was selected as a key study for the endpoint.

The endpoint study summary for 2-Propenoic acid, methyl ester, reaction products with 2-ethyl-1-hexanamine and sodium hydroxide (methanol free) is linked to study record(s) on the substance itself but also to study record(s) on an analogue substance, a.k.a. Sodium 3-[(2-carboxyethyl)(2-ethylhexyl)amino]propanoate (CAS RN 94441-92-6 / EC 305-318-6). The latter is used as source substance to fill datagaps on 2-Propenoic acid, methyl ester, reaction products with 2-ethyl-1-hexanamine and sodium hydroxide (methanol free) for particular endpoints pertaining to environmental fate, aquatic toxicity and human health toxicity. Several physico-chemical data are thus reported for the source substance (e.g.physical state, melting point, vapour pressure, surface tension, water solubility and n-octanol/water partition coefficient – identified as “supporting studies”) to support the read-across approach (cf. read-across justification document attached in "13 Assessment reports").