Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-506-8 | CAS number: 654-62-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no study available
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Skin corrosion/irritation
Experimental data on the potential of skin corrosion or irritation of 2,4-Disulfamyl-5-TMSA are not available.
In the classification provided by companies to ECHA in CLP notifications the substance causes serious eye irritation, causes skin irritation and may
cause respiratory irritation.
QSAR Toolbox, has identified one structural alert for skin irritation /corrosion. Substances with "Aromatic amines" as structural alert can cause
irritation of the skin if they are in the domains of applicability of the model proposed by Hulzebos et al..
The physicochemical property are used to define the domain of applicability, so the MW of 2,4 -Disulfamyl-5-TMSA is ca. 319.283 g/mol and the
predicted Log Kow is -0.188 (KOWWIN Program (v1.68)) and -0.32 predicted by VEGA; therefore, the compound is outside the applicability domain.
In order to estimates skin corrosion and irritation potential from physicochemical property ranges and structural rules, the software Toxtree
has been used and the substance has been predicted as Not Irritating or Corrosive.
Moreover, the Danish QSAR database contains information indicating that the substance is predicted for the “Severe Skin Irritation in Rabbit”
with the following results:
- NEG IN NEG IN NEG_OUT NEG_IN
(negative inside applicability domain, positive outside applicability domain)
Overall, available information are judged as inconclusive for the classification of the substance.
Serious eye damage/eye irritation
Experimental data on the potential of eye damage/eye irritation of 2,4-Disulfamyl-5-TMSA are not available.
In the classification provided by companies to ECHA in CLP notifications the substance causes serious eye irritation, causes skin irritation and may
cause respiratory irritation. Overall, available information are judged as inconclusive for the classification of the substance.
Specific target organ toxicity - single
Experimental data are not available. In the classification provided by companies to ECHA in CLP notifications the substance causes serious eye irritation, causes skin irritation and may cause respiratory irritation. Overall, available information are judged as inconclusive for the classification of the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
