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Diss Factsheets
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EC number: 213-067-8 | CAS number: 921-53-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- chronic toxicity: inhalation
- Type of information:
- other: publication
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see remarks
- Remarks:
- 1950 occupational exposure study of 15 individuals with long-term workplace exposure to tartaric acid dust. Does not allow interpretation following any inhalatory toxicity test guideline, but offers insight into effects and relevance of long-term exposure to tartaric acid dust.
- Justification for type of information:
- similar substance
Data source
Reference
- Reference Type:
- publication
- Title:
- Erosion of Teeth due to Tartaric Acid Dust
- Author:
- Elsbury, W.B., Browne, R.C., and Boyes, J.
- Year:
- 1 950
- Bibliographic source:
- Brit. J. Industr. Med., 1954, 8, 179.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Occupational case study
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 526-83-0
- Cas Number:
- 526-83-0
- IUPAC Name:
- 526-83-0
- Details on test material:
- The material to which the subjects were occupationally exposed is referred to in the study as "tartaric acid dust" in a tin making factory. This dust was quantitated gravimetrically and extimated to be at an airbourne concentration of 15 mg/m3. Percentual coposition of this powder was reported to be: 7.7% free tartaric acid; 22.5% combined tartaric acid; 16.5% sodium bicarbonate; 37.2% magnesium sulphate; 14.3% sucrose and 9.5% insoluble residue. Thereby the approximate amount of free and combined (tartrates) tartaric acid is estimated to account for 30.2% of the dust. Thereby the typical dust concentration of free and combined tartrates to which the workers were exposed results in approximately: 4.5 mg/m3
Constituent 1
- Specific details on test material used for the study:
- The material to which the subjects were occupationally exposed is referred to in the study as "tartaric acid dust" in a tin making factory. This dust was quantitated gravimetrically and extimated to be at an airbourne concentration of 15 mg/m3. Percentual coposition of this powder was reported to be: 7.7% free tartaric acid; 22.5% combined tartaric acid; 16.5% sodium bicarbonate; 37.2% magnesium sulphate; 14.3% sucrose and 9.5% insoluble residue. Thereby the approximate amount of free and combined (tartrates) tartaric acid is estimated to account for 30.2% of the dust. Thereby the typical dust concentration of free and combined tartrates to which the workers were exposed results in approximately: 4.5 mg/m3
Test animals
- Species:
- other: Occupational exposure - human
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- As a result of their occupation in a tin making company the effect of exposure to a reportedly "very dusty atmosphere" containing approximately 4.5 mg/m3 of free and combined tartaric acid was studied. The study describes exposures of 15 young individuals (females) for periods between 6 and 22 months, with weekly exposure times of 29 - 30 h to dust in mixing rooms were the substance was handled.
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- The occupational report describes effects of occupational exposure of 15 "girls" employed in a tin-making factory. Exposure takes place to dust in operations involving scooping powders out of drums, weighing, emptying them down chutes into hoppers and mixing . This generates a disty atmosphere to which the subjects are exposed unprotected for 29 - 30 h/ week for periods of 6 months to 22 months as reported in the study. Report indicates that although masks are supplied, these are not worn.
- Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- Composition of powder partially reported but analytical technique not described
- Duration of treatment / exposure:
- > 180 days
- Frequency of treatment:
- Workplace exposure, Daily, 5 days/week
Doses / concentrations
- Dose / conc.:
- 4.5 mg/m³ air
- Remarks:
- free and combined tartrates
- No. of animals per sex per dose:
- 15 young female employees exposed to approximately 4.5 mg/m3 free tartaric acid and tartrates.
- Control animals:
- other: 16 comparable individuals of same age and financial status working in another section of the tin making plant with no dust exposure
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Details on results:
- The report focuses on effects of the tartaric acid (and combined tartrates) which are inhaled and presumably retained in the mouth and upper respiratory tract. This leads to severely acidic saliva which on long term exposure leads to teeth erosion with progressive disappearance of the enamel and exposure of the dentine, leading to the eventual loss of the pieces. No other clinical signs of intoxication, respiratory distress or other lesions are reported.
Effect levels
- Dose descriptor:
- LOAEC
- Effect level:
- ca. 4.5 mg/m³ air (analytical)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other:
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Long term worker exposure to free tartaric acid and combined tartaric acid dust in conditions of high dustiness (ca. 4.5 mg/m3) for periods of 30 h/week for more than 6 months result in teeth erosion and progressive loss of dental pieces, but other clinical signs, morbidity or lethality are reported in a case study involving 15 youn females exposed in a tin-making company. Thereby the long term LD50 can be assumed to be well above 4.5 mg/m3.
- Executive summary:
The report focuses on effects of the tartaric acid (and combined tartrates) which are inhaled and presumably retained in the mouth and
upper respiratory tract. This leads to severely acidic saliva which on long term exposure leads to teeth erosion with progressive disappearance of the enamel and exposure of the dentine, leading to the eventual loss of the pieces.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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