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Diss Factsheets
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EC number: 205-531-3 | CAS number: 142-28-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Remarks:
- GESTIS selected data
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 980
- Reference Type:
- review article or handbook
- Title:
- GESTIS Substance Database 1,3-Dichloropropane
- Author:
- IFA Institue for Occupational Safety and Health of the German Social Accident Insurance
- Year:
- 2 018
- Bibliographic source:
- http://gestis-en.itrust.de/pdf/create/Data_sheet.php
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Methods for acute toxicity tests with fish, macroinvertebrates, and amphibians. U.S. EPA 1975
- Deviations:
- yes
- Remarks:
- described in detail in study report
- Principles of method if other than guideline:
- The Guideline is published by U.S. EPA in Methods for acute toxicity tests with fish, macroinvertebrates, and amphibians. Ecological Research Series (EPA-660/3-75-009), 61 pp. (1975)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,3-dichloropropane
- EC Number:
- 205-531-3
- EC Name:
- 1,3-dichloropropane
- Cas Number:
- 142-28-9
- Molecular formula:
- C3H6Cl2
- IUPAC Name:
- 1,3-dichloropropane
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Tested chemicals were purchased from commercial chemical suppliers and had a minimum purity of 80%.
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- yes
- Remarks:
- Test water was identical with culture water (see Details on test organisms)
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- 24 h old. 3 replicates with each 5 animals
Culture water was reconstituted according to U.S. EPA (Methods for acute toxicity tests with fish, macroinvertebrates, and amphibians. Ecological Research Series (EPA-660/3-75-009), 61 pp., 1975), to a total hardness of 173 +/- 13 mg/L (CaCO3) and a pH of 8.0 +/- 0.2
Study design
- Test type:
- static
- Water media type:
- freshwater
- Remarks:
- incubation water identical with culture water
- Limit test:
- no
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- 24 h also tested
Test conditions
- Hardness:
- 173 +/- 13 mg/L as CaCO 3
- Test temperature:
- 22 +/- 1 °C
- pH:
- 8.0 +/- 0.2; the range of pH values measured was 7.4-9.4.
- Dissolved oxygen:
- greater than 60% of saturation. Dissolved oxygen concentration and temperature were measured with a combined oxygen-temperature probe (YSI Model 54BP dissolved oxygen meter). Dissolved oxygen concentrations ranged from 6.5 to 9.1 mg/L during the 48 h exposure period. Within any one test, the greatest range observed was 6.6-8.1 mg/L.
- Salinity:
- fresh water, reconstituted according to U.S. EPA: Methods for acute toxicity tests with fish, macroinvertebrates, and amphibians. Ecological Research Series (EPA-660/3-75-009), 61 pp. (1975), identical with Culture water
- Conductivity:
- not measured
- Nominal and measured concentrations:
- nominal
- Reference substance (positive control):
- not specified
- Remarks:
- testing of several substances of diverse chemical groups
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- >= 200 - <= 390 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: LC50 = 280 mg/L
- Key result
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- >= 360 - <= 710 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: LC50 = 490 mg/L
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 68 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- LC50 Daphnia magna (48 hours): 280 mg/L
- Executive summary:
Short term toxicity to aquatic invertebrates was measured according to U.S. EPA in Methods for acute toxicity tests with fish, macroinvertebrates, and amphibians. Ecological Research Series (EPA-660/3-75-009), 61 pp. (1975), which is in principle similar to current guidelines. The LC50 of 1,3 -Dichloropropane on Daphnia magna (48 hours) is 280 mg/L.
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