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EC number: 272-657-3 | CAS number: 68901-15-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 Apr - 02 May 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- No information on purity was given.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1981
- Deviations:
- yes
- Remarks:
- No information on purity was given.
- GLP compliance:
- no
- Remarks:
- Basic documentation of quality assurance of experimental procedures and study report available, but not comparable to nowadays GLP provisions
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Allyl (cyclohexyloxy)acetate
- EC Number:
- 272-657-3
- EC Name:
- Allyl (cyclohexyloxy)acetate
- Cas Number:
- 68901-15-5
- Molecular formula:
- C11H18O3
- IUPAC Name:
- allyl (cyclohexyloxy)acetate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- BOR: WISW (SPF TNO)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 199.4 - 247.0 g (males), 150.0 - 187.2 g (females)
- Fasting period before study: food was withdrawn 16 h prior to and approx. 4 h after dosing.
- Housing: in groups of maximum 5 in Makrolon cages (Typ III), sawdust was used as bedding material
- Diet: Ssniff-R Alleindiät für Ratten (Ssniff Spezialfutter GmbH, Soest, Germany), ad libitum
- Water: tap water, ad libitum
- Acclimation period: minimum 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 2
- Humidity (%): 50 - 85
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Details on oral exposure:
- A range-finding study was carried out to establish a dosing regimen for the main study.
VEHICLE
- Concentration in vehicle: 25%
MAXIMUM DOSE VOLUME APPLIED: approx. 4 mL/kg bw - Doses:
- Range-finding study: 1.0 and 2.5 mL/kg bw (corresponding to 1020 and 2550 mg/kg bw based on density of 1.02 g/cm³); 500 and 750 mg/kg bw
Main study: 250, 500, 750 and 1000 mg/kg bw - No. of animals per sex per dose:
- Range-finding study: 2 females
Main study: 5 males and 5 females - Control animals:
- no
- Details on study design:
- Range-finding study:
- Duration of observation period following administration: 14 days
- Frequency of observations: Animals were observed 20 min and 1, 2, 3, 6, 24 and 48 h after administration and subsequently once daily for 14 days.
Main study:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed 20 min and 1, 2, 3, 6, 24 and 48 h after administration and subsequently once daily for 14 days. Individual body weights were determined on Days 0 and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- Probit Analysis according to Finney (1971) was used to calculate the orale LD50 values.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 620.42 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Range-finding study: All animals died at approx. 1020 and 2550 mg/kg bw within 24 h after administration. No mortality occurred at 500 and 750 mg/kg bw.
Main study: At 250 mg/kg bw no mortality occurred during the study period. At 500 mg/kg bw three animals died within 3 days after administration. At 750 mg/kg bw five animals died within 6 days after administration. At 1000 mg/kg bw all animals died within 3 days after administration. - Clinical signs:
- other: Main study: The test substance induced apathy, posture anomalies, ataxia, decreased excitability, piloerection, ptosis and dark red coloured urine. The symptoms occurred in surviving animals approx. 20 min post administration and continued with first incr
- Gross pathology:
- Gross pathological examination of dead animals revealed partially severe gastrointestinal haemorrhages and one urinary bladder filled with bloody urin.
Post mortem examination of rats surviving until scheduled sacrifice on Day 14 revealed no abnormalities.
Any other information on results incl. tables
Table 1. Results of the acute toxicity study.
Group |
Dose level (mg/kg bw) |
Mortality |
|||||||
24 h |
48 h |
7 days |
6/14 days |
||||||
m |
f |
m |
f |
m |
f |
m |
f |
||
I |
250 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
II |
500 |
0/5 |
0/5 |
0/5 |
1/5 |
1/5 |
2/5 |
1/5 |
2/5 |
III |
750 |
0/5 |
3/5 |
0/5 |
3/5 |
1/5 |
3/5 |
1/5 |
4/5 |
IV |
1000 |
2/5 |
4/5 |
3/5 |
5/5 |
5/5 |
5/5 |
5/5 |
5/5 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- In this acute oral toxicity study a LD50 value of 620.42 mg/kg bw in male and female rats was calculated according to the method of Finney.
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