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Diss Factsheets
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EC number: 203-317-4 | CAS number: 105-64-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 958
- Report date:
- 1958
Materials and methods
- Principles of method if other than guideline:
- Acute toxic method
- GLP compliance:
- no
- Test type:
- traditional method
Test material
- Reference substance name:
- Bisisopropyl peroxydicarbonate
- EC Number:
- 203-317-4
- EC Name:
- Bisisopropyl peroxydicarbonate
- Cas Number:
- 105-64-6
- Molecular formula:
- C8H14O6
- IUPAC Name:
- 2-[({[(propan-2-yloxy)carbonyl]peroxy}carbonyl)oxy]propane
- Details on test material:
- SMILES (used for QSAR prediction): C(=O)(OC(C)C)OOC(=O)OC(C)C
Molecular Formula: C8 H14 O6
Molecular weight (g/mole): 206.2
Constituent 1
- Specific details on test material used for the study:
- Isopropyl Peroxycarbonate on June 3, 1957 from Mr. Lynn King, Columbia-Southern Chemical Corp., Barberton, Ohio.
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200-250 grams
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Details on inhalation exposure:
- A group of ten animals was placed in a closed but not sealed stainless steel chamber measuring 12 in. x 18 in. x 2.4 in. The rats were placed on a wire mesh false bottom about 2. in. above the chamber floor. A stream of cool water upon the outside of the chamber served to cool it and to dissipate the body heat of the animals. The solid test material was added slowly over a period of eight hours. A total of 48 grams of the solid sample waa added over the test period through a loosely covered circular hole one inch in diameter in the side of the chamber onto the chamber floor.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Concentrations:
- Saturated vapor concentration of bisisopropyl peroxydicarbonate and/or its degradation products
- No. of animals per sex per dose:
- 10
- Details on study design:
- Immediately after exposure and again one week later five animals were sacrificed. Their lungs were removed, fixed and submitted for histological e:xamination.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC0
- Exp. duration:
- 8 h
- Remarks on result:
- other: Saturated vapor concentration of bisisopropyl peroxydicarbonate and/or its degradation products
- Remarks:
- No symptoms of abnormality or distress
- Mortality:
- None
- Clinical signs:
- other: No symptoms of abnormality or distress attributable to the sample were noted during the exposure period. Similarly no effects were observed in those animals maintained for a one week period after treatment on a normal laboratory routine.
- Gross pathology:
- The histopathological report of the examination of the lungs of these animals revealed no significant effects due to the treatment.
Applicant's summary and conclusion
- Executive summary:
No symptoms of abnormality and histopathological changes in lungs were noted during a 8-hour inhalation exposure to saturated vapor concentration of bisisopropyl peroxydicarbonate and/or its degradation products.
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