Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 810-288-7 | CAS number: 1700656-13-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012-11-02 to 2012-11-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- and Directive 2001/59/EC Method C.19
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- other: soil and sewage sludge
- Radiolabelling:
- no
- Test temperature:
- The column temperature during the study was monitored every 2 minutes by a data logger. A mean value of 22.9 °C was obtained for the temperature during the course of the study.
Temperature Range
Temperature [°C]
Min. 22.8
Max. 23.1
Mean Value 22.9 - Details on study design: HPLC method:
- EQUIPMENT
- Apparatus:
HPLC AGILENT 1100 consisting of:
Auto sampler : G1329A
Auto sampler thermostat: G1330B
Degasser: G1322A
Column oven: G1316A
Detector (test system): G1315B
Pump: G1312A
Software: Empower 2 (Build No: 2154), Waters
CONDITIONS OF ANALYSIS
HPLC-column: YMC-Pack CN, 250 x 4.0 mm, S-5 µm, 12 nm, Gel. lot 11334,
YMC EUROPE GMBH
Column temperature 20-25 °C
Additional Equipment Analytical balance, SARTORIUS
Data logger/thermometer TESTO 175-T3
Direct displacement pipettes, GILSON
Laboratory glassware
Piston stroke pipettes, THERMO SCIENTIFIC
Top pan balance, KERN
Mobile phase Acetonitrile : HPLC water (55 : 45)
REFERENCE SUBSTANCES
- Identity: Reference Substances for Adsorption Coefficient in Soil and Sewage Sludge:
Reference item CAS-No. log KOC, soil log KOC, sewage sludge
Acetanilide 103-84-4 1.26 1.52
Monuron 150-68-5 1.99 1.46
Atrazine 1912-24-9 1.81 1.66
Linuron 330-55-2 2.59 2.43
Benzoic acid 93-99-2 2.87 3.26
phenylester
Fenthion 55-38-9 3.31 3.75
Phenanthrene 85-01-8 4.09 4.35
DDT 50-29-3 5.63 -
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: Approx. 55 mg/L
- Quantity of reference substances: Approx. 5 mg/L
- Intervals of calibration: Set of reference substance - one before and one after the test item
REPETITIONS
- Number of determinations:
Test item: Single replicate (three injections)
Reference item:
Two injections (one before and one after the analysis of the test item)
Three injections for NaNO3 at the beginning of the sample set.
EVALUATION
- Calculation of capacity factors k': k = (tR-t0)/t0
- Determination of the log Koc value:
By linear regression of the log KOC of the reference items against the log k’ of the reference items the equation for the calibration graph was obtained.
Two individual adsorption coefficient log KOC for the test item were calculated by experimentally determining its capacity factor k’ and inserting k’ into the equations obtained from the first and second calibration graph:
logKoc = a*logk'+b
a: slope of the calibration graph, b: y-intercept of calibration graph
Finally, a mean value was calculated from these individual log KOC values for soil and for sewage sludge, respectively. - Analytical monitoring:
- not required
- Type:
- log Koc
- Value:
- 3.8 dimensionless
- Matrix:
- Soil
- Type:
- log Koc
- Value:
- 4 dimensionless
- Matrix:
- Sewage sludge
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration:
Capacity Factors (k’) of the Reference Items for Soil and Sewage Sludge
Reference item log KOC, log KOC 1st Calibration 2nd Calibration
soil sewage sludge tR1 [min] k' log k' tR2 [min] k' log k'
Acetanilide 1.26 1.52 2.881 1.340 0.127 2.877 1.337 0.126
Monuron 1.99 1.46 3.267 1.654 0.219 3.261 1.649 0.217
Atrazine 1.81 1.66 3.439 1.794 0.254 3.433 1.789 0.253
Linuron 2.59 2.43 4.345 2.530 0.403 4.339 2.525 0.402
Benzoic acid 2.87 3.26 4.978 3.044 0.483 4.970 3.037 0.482
phenylester
Fenthion 3.31 3.75 5.960 3.842 0.585 5.951 3.834 0.584
Phenanthrene 4.09 4.35 5.997 3.872 0.588 5.988 3.864 0.587
4,4’-DDT 5.63 - 10.674 7.333 0.865 10.675 7.333 0.865
tR1 = Retention time 1. Injection; tR2 = Retention time 2. Injection
k’ = Capacity factor; KOC = Adsorption coefficient
The corresponding calibration data for the corresponding calibration lines are summarized in the table below. The calibration data were obtained from the regression line of the graph log KOC vs. log k’.
Calibration Data of the Reference Items for Soil and Sewage Sludge
Soil Sewage Sludge
1st Calibration 2nd Calibration 1st Calibration 2nd Calibration
slope 5.691 5.682 6.127 6.123
intercept 0.4368 0.4465 0.3055 0.3140
r2 0.9563 0.9563 0.9268 0.9271
r 0.9779 0.9779 0.9627 0.9629
r : Correlation Coefficient; r2 : Coefficient of determination
- Average retention data for test substance:
Soil:
Two individual log KOC values for the test item were derived under consideration of the first and second calibration. Finally, a mean value was calculated from these individual log KOC values for soil.
An individual log KOC value of 3.8 ± 0.1 (95 % CI 3.5 to 4.2) was obtained with both calibrations. The individual values did not differ more than ± 0.25 log KOC values. Based on these data a mean value of 3.8 was derived.
Retention Times, Capacity Factors (k’) and Adsorption Coefficient (KOC) of Antimussol ZJ for soil
log KOC, soil 95 % CI
tR [min] k' log k' 1st Calibration 2nd Calibration
Antimussol ZJ
6.103 3.96 0.5975 3.8 ± 0.1 3.8 ± 0.1
6.102 3.96 0.5974 3.5 to 4.2 3.5 to 4.2
6.099 3.95 0.5971
Mean 6.101 3.96 0.5973 3.8
tR = Retetntion time
CI = Confidence Interval
Sewage:
Two individual log KOC values for the test item were derived under consideration of the first and second calibration. Finally a mean value was calculated from these individual log KOC values for sewage sludge.
An individual log KOC value of 4.0 ± 0.2 (95 % CI 3.4 to 4.5) was obtained with both calibrations. The individual values did not differ more than ± 0.25 log KOC values. Based on these data a mean value of 4.0 was derived.
Retention Times, Capacity Factors (k’) and Adsorption Coefficient (KOC) of Antimussol ZJ for Sewage Sludge
log KOC, soil 95 % CI
tR [min] k' log k' 1st Calibration 2nd Calibration
Antimussol ZJ
6.103 3.96 0.5975 4.0 ± 0.2 4.0 ± 0.2
6.102 3.96 0.5974 3.4 to 4.5 3.4 to 4.5
6.099 3.95 0.5971
Mean 6.101 3.96 0.5973 4.0
tR = Retetntion time
CI = Confidence Interval
- Validity criteria fulfilled:
- yes
- Conclusions:
The adsorption coefficient log KOC of the test item Antimussol ZJ was determined to be 3.8 for soil and 4.0 for sewage sludge.- Executive summary:
The adsorption coefficient (KOC) on soil and on sewage sludge using high performance liquid chromatography (HPLC) was estimated according to OECD/OCDE 121 (2001) and Council Regulation (EC) No. 440/2008, Method C.19 for the test itemAntimussol ZJ (batch number:ESD0015431)from 2013-11-21 to 2013-12-20 at Dr.U.Noack‑Laboratorien, 31157 Sarstedt, Germany.
The test was performed temperature controlled, (22.9 °C, mean value) with a mobile phase consisting of 55 % acetonitrile and 45 % HPLC water. A 55mg/L sample of the test item Antimussol ZJ was analyzed threefold via HPLC on a cyanopropyl (CN-) column with PDA‑detection.
Calibrations were performed using eight reference items for soil and seven for sewage sludgewith known logKOCvalues (given by the guidelines). The reference items were measured twice, once before and once after the measurement (double injection of one replicate) of the test item. Dead time of the HPLC-system was determined with sodium nitrate.
Two individual logKOCvalues for soil and for sewage sludge forthe test item were derived under consideration of the first and second calibration. Finally, a mean valuefor soil and for sewage sludgewas calculated from these individual logKOCvalues. Based on these data a logKOCof 3.8 for soil and a logKOCof 4.0 for sewage sludge were determined for Antimussol ZJ.
Test Item
AntimussolZJ
logKOC, soil
logKOC,sewage sludge
1stCalibration
2ndCalibration
1stCalibration
2ndCalibration
3.8 ± 0.1
3.5 to 4.2 (95 % CI)3.8 ± 0.1
3.5 to 4.2 (95 % CI)4.0 ± 0.2
3.4 to 4.5 (95 % CI)4.0 ± 0.2
3.4 to 4.5 (95 % CI)Mean
3.8
4.0
KOC : Adsorption coefficient
CI : Confidence Interval
The adsorption coefficient logKOCforAntimussol ZJ was determined to be 3.8 for soil
and 4.0 for sewage sludge.
Reference
Dead Time of the HPLC-System
Serial No. |
t0 |
t0only for DDT |
1 |
1.230 |
1.280 |
2 |
1.231 |
1.282 |
3 |
1.232 |
- |
Mean ± SD |
1.231±0.001 |
1.281±0.001 |
Description of key information
The adsorption coefficient log KOC of the test item Antimussol ZJ was determined to be 3.8 for soil and 4.0 for sewage sludge.
Key value for chemical safety assessment
- Koc at 20 °C:
- 6 309
Additional information
[LogKoc: 3.8]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.