Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 218-345-2 | CAS number: 2128-93-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Administrative data
First-aid measures
Description of first aid measures
General indications: IF exposed or concerned: Get medical advice/attention. The first responders must always wear appropriate personal protective equipment (see SECTION 8.2).
Contact with the eyes: Rinse cautiously with water for several minutes, holding the eyelids open. If eye irritation occurs, immediately call a doctor.
Contact with the skin: Take off immediately all contaminated clothing. Wash with plenty of water and soap. If skin irritation/eruption occurs, immediately call a doctor.
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing. Give oxygen and immediately call a doctor, if you feel unwell. If breathing has stopped, administer artificial respiration (by trained personnel).
Ingestion: Rinse mouth with water. Do not induce vomiting, unless recommended by a doctor. Never give anything by mouth if the person is not conscious. If you feel unwell, immediately call a POISON CENTER.
Most important symptoms and effects, both acute and delayed
General indications: The substance has not been fully investigated from a toxicological point of view.
Contact with the eyes: It may cause irritation with redness and tearing.
Contact with the skin: It may cause irritation with redness and erythema at the contact area.
Inhalation: It may cause drowsiness or dizziness, irritation of the mucous membranes, coughing and shortness of breath.
Ingestion: It may cause disorders of the gastrointestinal tract, with nausea, diarrhea and vomiting.
Indication of any immediate medical attention and special treatment needed
For indication of any immediate medical attention, see Description of first aid measures (SECTION 4.1). Basic first aid and symptomatic treatment. Symptoms of poisoning may occur even at a later stage after the exposure; therefore, medical surveillance is recommended for 48 hours after the accident.
Fire-fighting measures
Extinguishing media
Suitable: Use extinguishing media appropriate to the source of the fire and the surrounding area (e.g. water spray, carbon dioxide, dry chemical powder or foam).
Unsuitable: Water jet.
Special hazards arising from the substance or mixture
The substance is neither flammable nor explosive.
Advice for firefighters
Operate in accordance with the provisions of the fire control plan. Evacuate and isolate the area until complete fire extinction, by limiting access only to trained personnel. Firefighters must always wear appropriate protective equipment: positive pressure self-contained breathing apparatus; fireproof clothing; fireproof gloves; firefighter’s boots. Ensure adequate ventilation. Avoid breathing gases/vapours and contact with eyes, skin and clothing. Stay upwind. Remove containers if it can be done without risk. Alternatively, cool the recipients exposed to fire with water spray. Prevent the contaminated extinguishing water flowing into drains or waterways.
Accidental release measures
Personal precautions, protective equipment, and procedures in case of emergency
Operate in accordance with the provisions of the emergency plan. Alert the emergency personnel. Evacuate and isolate the area until complete dispersion of the substance and restrict the access only to trained personnel. Ensure adequate ventilation. Avoid breathing dust/mist/vapours and contact with eyes and skin. Wear appropriate personal protective equipment (see SECTION 8.2).
Environmental precautions
Prevent the substance from leaking into the environment and run off into drains, surface waters and groundwater. Alert competent authorities if large amounts into drains or watercourses.
Methods and material for containment and cleaning up
Contain the spillage. Adsorb with an inert material. Collect with mechanical means and transfer in a properly labeled container. Dispose of in accordance with local and national legislation. Clean surface thoroughly in order to remove residual contamination.
Handling and storage
This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates. Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at the manufacturing site.
Precautions for safe handling
The work place and work methods shall be organized in such a way that direct contact with the substance is prevented or minimized. Ensure adequate ventilation. Avoid breathing dust/mist/vapours and contact with eyes and skin. Wear appropriate personal protective equipment (see SECTION 8.2). Do not eat, drink, or smoke during use. Wash hands and other exposed areas after use. Wash periodically clothes and personal protective equipment to remove contaminants. Handle in accordance with good industrial hygiene and safety practices.
Conditions for safe storage, including any incompatibilities
Store in a cool, dry and well ventilated place. Avoid exposure to moisture and direct sunlight. Keep away from heat/sparks/open flames. Avoid the accumulation of static discharges. Store away from incompatible materials (see SECTION 10.5).
Specific end use(s)
Pharmaceutical intermediate.
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- Not applicable
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Inland waterway transport (UN RTDG/ADN(R))
- UN number:
- Not applicable
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Marine transport (UN RTDG/IMDG)
- UN number:
- Not applicable
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Air transport (UN RTDG/ICAO/IATA)
- UN number:
- Not applicable
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Exposure controls / personal protection
This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates. Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at the manufacturing site.
Control parameters
The substance has no occupational exposure limit values.
Exposure controls
Wear personal protective equipment in accordance with standards set by European and national legislation. Consult the supplier in all cases before making a final decision.
Skin protection: Wear protective clothing with long sleeve.
Hand protection: Wear work gloves impervious to chemicals made of nitrile rubber.
Eye protection: Wear appropriate safety glasses with side shields.
Respiratory protection: In the case of vapour formation, wear a respirator with an approved filter.
Technical and hygienic measures: Provide local exhaust ventilation suction or other devices to maintain the levels of particles in the air below the recommended exposure limits. Equip the plant with exhaust hoods or equivalent dust collection devices. Equip with emergency showers and eyewash device the areas in which handling and storage of the product takes place. Do not eat, drink, or smoke during use. Wash hands and other exposed areas after use. Wash periodically clothes and personal protective equipment to remove contaminants. Handle in accordance with good industrial hygiene and safety practices.
Stability and reactivity
Reactivity: The substance is not reactive under recommended conditions of use.
Chemical stability: The substance is stable under recommended conditions of use and storage.
Possibility of hazardous reactions: The possibility of hazardous reactions is not expected under recommended conditions of use and storage.
Conditions to avoid: Avoid exposure to moisture and direct sunlight. Keep away from heat/sparks/open flames.
Incompatible materials: Not known.
Hazardous decomposition products: Not expected.
Disposal considerations
This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates. Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at the manufacturing site.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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